Dolin R, Wise T G, Mazur M H, Tuazon C U, Ennis F A
J Infect Dis. 1977 Dec;136 Suppl:S435-42. doi: 10.1093/infdis/136.supplement_3.s435.
Inactivated influenza A/New Jersey/76 virus vaccines were administered intramuscularly to 199 normal adults, aged 19-59, in doses of 200, 400, or 800 chick cell-agglutinating units in a double-blind, placebo-controlled trial. Systemic reactions (including fever) were uncommon, were mild, lasted less than 24 hr, and were more frequently associated with the largest dose. Local reactions were common but mild. A single, rapidly reversible, allergic reaction was noted in a volunteer 2 hr after vaccination. There was a trend toward fewer systemic reactions in vaccines who had preexisting hemagglutination-inhibiting (HAI) antibodies to the vaccine virus in their sera as compared with seronegative vaccines. All vaccine preparations at all three dosages evoked serum HAI titers of greater than or equal to 20 to greater than or equal to 40 in a high proportion of seronegative recipients, with significantly greater geometric mean titers at the highest dosage. Vaccines between the ages of 19 and 23 years manifested significantly lower serologic responses than did vaccinees over the age of 23. Thus, normal adults over the age of 23 can be immunized with a single, well-tolerated dose of A/New Jersey/76 vaccines.
在一项双盲、安慰剂对照试验中，将灭活的甲型流感/新泽西/76病毒疫苗以200、400或800鸡胚细胞凝集单位的剂量肌肉注射给199名年龄在19至59岁的正常成年人。全身反应（包括发热）不常见，症状轻微，持续时间不到24小时，且与最大剂量的关联更频繁。局部反应常见但轻微。一名志愿者在接种疫苗2小时后出现了一次单一的、可迅速逆转的过敏反应。与血清阴性的接种者相比，血清中预先存在针对疫苗病毒的血凝抑制（HAI）抗体的接种者出现全身反应的趋势较少。所有三种剂量的疫苗制剂在高比例的血清阴性接受者中都引发了大于或等于20至大于或等于40的血清HAI滴度，最高剂量时的几何平均滴度显著更高。19至23岁的接种者表现出的血清学反应明显低于23岁以上的接种者。因此，23岁以上的正常成年人可以用单剂耐受性良好的甲型流感/新泽西/76疫苗进行免疫接种。
