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孕妇对单价A/新泽西/8/76流感疫苗的抗体反应。

Antibody response to monovalent A/New Jersey/8/76 influenza vaccine in pregnant women.

作者信息

Murray D L, Imagawa D T, Okada D M, St Geme J W

出版信息

J Clin Microbiol. 1979 Aug;10(2):184-7. doi: 10.1128/jcm.10.2.184-187.1979.

Abstract

The decision to implement a mass immunization program with A/New Jersey/8/76 (Hsw1N1) influenza vaccine provided a unique opportunity to evaluate immunological responses during pregnancy. Fifty-nine pregnant and 27 nonpregnant women participated in this study. Influenza virus hemagglutination-inhhibition antibody titers were determined to A/New Jersey/8/76 (Hsw1N1), A/Japan/305/57 (H2N2), and A/Hong Kong/8/68 (H3N2) before and after a single dose of monovalent (200 chick cell agglutination units) influenza A/New Jersey/8/76 (Hsw1N1) vaccine. The difference in titers between pregnant and nonpregnant women was insignificant. Treatment of the sera with 2-mercaptoethanol disclosed a similar immunoglobulin M response to the vaccine in both groups. The mean fold rise in heterologous antibody titer was similar in pregnant and nonpregnant women. This study demonstrated that pregnant women were able to respond to an original myxovirus antigen, influenza A/New Jersey/8/76, in a manner equivalent to nonpregnant, age-matched controls.

摘要

实施针对A/新泽西/8/76(Hsw1N1)流感疫苗的大规模免疫计划的决定,为评估孕期的免疫反应提供了一个独特的机会。59名孕妇和27名非孕妇参与了这项研究。在接种单剂量单价(200鸡胚细胞凝集单位)A/新泽西/8/76(Hsw1N1)流感疫苗前后,测定了针对A/新泽西/8/76(Hsw1N1)、A/日本/305/57(H2N2)和A/香港/8/68(H3N2)的流感病毒血凝抑制抗体滴度。孕妇和非孕妇之间的滴度差异不显著。用2-巯基乙醇处理血清后发现,两组对疫苗的免疫球蛋白M反应相似。孕妇和非孕妇中异源抗体滴度的平均升高倍数相似。这项研究表明,孕妇对原始黏液病毒抗原A/新泽西/8/76的反应能力与年龄匹配的非孕妇对照组相当。

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本文引用的文献

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Teratogenic effects of Asian influenza.亚洲流感的致畸作用。
J Am Med Assoc. 1959 Oct 10;171:638-41. doi: 10.1001/jama.1959.03010240006003.
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Serum immunogbulin cocentrations during normal pregnancy.正常孕期的血清免疫球蛋白浓度。
Am J Obstet Gynecol. 1971 Apr 1;109(7):971-6. doi: 10.1016/0002-9378(71)90275-4.
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