Children's Nutrition Research Center, Children's Hospital of Chongqing Medical University, Chongqing Key Laboratory of Childhood Nutrition and Health, Chongqing, 400014, China.
Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, National Clinical Research Center for Child Health and Disorders, Chongqing, 400014, China.
J Autism Dev Disord. 2022 Jul;52(7):3116-3128. doi: 10.1007/s10803-021-05066-w. Epub 2021 Jul 14.
Metabolic disturbance may be implicated in the pathogenesis of autism. This study aimed to investigate the gut metabolomic profiles of autistic children and to analyze potential interaction between gut metabolites with autistic symptoms and neurodevelopment levels. We involved 120 autistic and 60 neurotypical children. Autistic symptoms and neurodevelopment levels were assessed. Fecal samples were analyzed using untargeted liquid chromatography-tandem mass spectrometry methods. Our results showed the metabolic disturbances of autistic children involved in multiple vitamin and amino acid metabolism pathways, with the strongest enrichment identified for tryptophan metabolism, retinol metabolism, cysteine-methionine metabolism, and vitamin digestion and absorption. Differential gut metabolites were correlated to autistic symptoms and neurodevelopment levels. Our findings improved the understanding of the perturbations of metabolome networks in autism.
代谢紊乱可能与自闭症的发病机制有关。本研究旨在探讨自闭症儿童的肠道代谢组特征，并分析肠道代谢物与自闭症症状和神经发育水平之间的潜在相互作用。我们纳入了 120 名自闭症儿童和 60 名神经正常儿童。评估了自闭症症状和神经发育水平。使用非靶向液相色谱-串联质谱方法分析粪便样本。我们的结果表明，自闭症儿童的代谢紊乱涉及多种维生素和氨基酸代谢途径，其中色氨酸代谢、视黄醇代谢、半胱氨酸-蛋氨酸代谢和维生素消化吸收途径的富集最为明显。差异肠道代谢物与自闭症症状和神经发育水平相关。我们的研究结果提高了对自闭症代谢组网络紊乱的认识。
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