Suárez-Jaramillo Andrés, Cifuentes Sara G, Baldeón Manuel, Cárdenas Paúl
Institute of Microbiology, Universidad San Francisco de Quito, Quito 170901, Ecuador.
Facultad de Ciencias Médicas de la Salud y de la Vida, Universidad Internacional del Ecuador, Quito 170411, Ecuador.
Metabolites. 2025 Mar 21;15(4):213. doi: 10.3390/metabo15040213.
: Currently, the diagnosis of autism spectrum disorder (ASD) relies on behavioral observations, frequently causing delays in early identification. Prognostic markers are essential for customizing therapy and monitoring progress. However, there are currently no recognized biomarkers for ASD. The current systematic review aims to analyze studies on the intestinal metabolome in children (both autistic and non-autistic) to identify potential metabolites for diagnostic and prognostic purposes. : We searched Medline, Scopus, Embase, and Web of Science for relevant publications. : We identified 11 studies examining the gut metabolome that distinguished between autistic and non-autistic children. These studies also revealed connections between gut metabolites, developmental scores, and symptoms. The substances identified were associated with metabolic pathways such as amino acids, vitamins, lipids, oxidative stress, glycans, xenobiotics, and nucleotides. : These findings suggest metabolic changes that may be linked to the causes or development of autism. Although these observations came from a few reports, only high-quality studies were included in this review. Further research is essential to confirm the identified substances as biomarkers.
目前，自闭症谱系障碍（ASD）的诊断依赖于行为观察，这常常导致早期识别出现延迟。预后标志物对于定制治疗方案和监测进展至关重要。然而，目前尚无公认的ASD生物标志物。当前的系统评价旨在分析关于儿童（包括自闭症儿童和非自闭症儿童）肠道代谢组的研究，以确定用于诊断和预后目的的潜在代谢物。：我们在Medline、Scopus、Embase和科学网中检索相关出版物。：我们确定了11项研究肠道代谢组的研究，这些研究区分了自闭症儿童和非自闭症儿童。这些研究还揭示了肠道代谢物、发育评分和症状之间的联系。所确定的物质与氨基酸、维生素、脂质、氧化应激、聚糖、外源性物质和核苷酸等代谢途径有关。：这些发现表明代谢变化可能与自闭症的病因或发展有关。尽管这些观察结果来自少数报告，但本综述仅纳入了高质量研究。进一步的研究对于确认所确定的物质为生物标志物至关重要。
