Finlay Warren H
Department of Mechanical Engineering, University of Alberta, Alberta, Canada.
J Aerosol Med Pulm Drug Deliv. 2021 Aug;34(4):213-216. doi: 10.1089/jamp.2021.29040.whf. Epub 2021 Jul 14.
Of the various particle properties that affect deposition in the respiratory tract, particle diameter and particle density are the most commonly considered, since their effect on deposition is well known and important, as has been discussed earlier in this chapter. However, there are several other particle properties that can affect particle deposition in the lungs. These include: 1) electrostatic charge on the particle, which can cause electrostatic forces to enhance deposition; 2) the shape of the particle, which can cause its trajectory to differ from that of a spherical particle and thereby alter its deposition; and 3) volatility of the particle i.e., its ability to condense or evaporate at its surface, which can change its diameter and in turn affect its deposition. In this section, we examine each of these three factors individually.
在影响呼吸道内沉积的各种颗粒特性中，颗粒直径和颗粒密度是最常被考虑的，因为它们对沉积的影响是众所周知且很重要的，正如本章前面所讨论的那样。然而，还有其他几个颗粒特性会影响颗粒在肺部的沉积。这些特性包括：1）颗粒上的静电荷，它可导致静电力增强沉积；2）颗粒的形状，它可使其轨迹不同于球形颗粒，从而改变其沉积；3）颗粒的挥发性，即其在表面冷凝或蒸发的能力，这可改变其直径，进而影响其沉积。在本节中，我们将分别研究这三个因素。
