Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, Milano, Italy.
Department of Science and High Technology DiSAT, Università degli Studi dell'Insubria, Como, Italy.
Regul Toxicol Pharmacol. 2021 Oct;125:105003. doi: 10.1016/j.yrtph.2021.105003. Epub 2021 Jul 12.
The paper aims to propose a new method to evaluate the occupational exposure risk for examiners involved in dynamic olfactometry. Indeed, examiners are possibly exposed to hazardous pollutants potentially present in odorous samples. A standardized method to evaluate the examiners' occupational safety is not yet available and the existing models present some critical aspect if applied to real odorous samples (no uniform reference concentrations applied and presence of compounds for which no toxicity threshold is available). A deepening of assessment procedure to evaluate the occupation exposure risk for olfactometric assessors is necessary. This paper proposes a standardized approach for risk assessment in dynamic olfactometry. The proposed approach allows the quantification synthetic and conservative risk indices. In this model, the use of the hazard index for the odorous mixture was proposed to assess the non-carcinogenic risk; the calculation of the inhalation risk was applied to estimate the carcinogenic risk. Different databases can be used to retrieve proper occupational exposure limits, according to the proposed hierarchical basis. These implementations allow obtaining the complete characterization of real samples which can be used to calculate the minimum dilution factor for protecting the panellists' health.
本文旨在提出一种新方法来评估参与动态嗅闻法测试的评估师的职业暴露风险。实际上，评估师可能会接触到可能存在于有气味样品中的危险污染物。目前还没有评估评估师职业安全的标准化方法，而现有的模型如果应用于实际有气味的样品，则存在一些关键方面（没有应用统一的参考浓度，并且存在没有毒性阈值的化合物）。有必要深入评估程序，以评估嗅闻评估师的职业暴露风险。本文提出了一种用于动态嗅闻法风险评估的标准化方法。所提出的方法允许量化综合和保守的风险指数。在该模型中，提出了使用恶臭混合物的危害指数来评估非致癌风险；应用吸入风险的计算来估计致癌风险。根据提出的分层基础，可以使用不同的数据库来检索适当的职业暴露限值。这些实施允许获得真实样品的完整特征，可用于计算保护评估员健康的最小稀释因子。
