Xie Feng, Qian Xiaoqing, Li Ning, Cui Daxiang, Zhang Hao, Xu Zhiyun
Department of Cardiovascular Surgery, Changhai Hospital, Naval Military Medical University, Shanghai, China.
School of Biomedical Engineering, Shanghai Jiaotong University, Shanghai, China.
Ann Transl Med. 2021 May;9(9):800. doi: 10.21037/atm-21-1707.
Scavenging energy from biomechanical motions by energy converting devices, i.e., implantable harvesters, to obtain sustainable electrical energy is the ideal way to power implantable medical devices which require long term and continuous power supply. A novel self-powered cardiac pacemaker is designed to achieve self-powered pacing. The kinetic energy of the heart was collected by an implanted piezoelectric energy collector and supplied to the cardiac pacemaker, and then the cardiac tissue was stimulated by the pacing electrode pierced from the outside of the heart to realize effective pacing effect and self-powered pacing. In this study, we evaluated the stability and biocompatibility of our previously described flexible buckling piezoelectric vibration energy harvester and . The biocompatibility, stability, and safety of the self-powered pacemaker with a flexible flexion piezoelectric vibratory energy harvesting device prepared were analyzed by performing cell and animal experiments.
The MTT(3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay was used to detect the cell proliferation of H9C2 cells and HUVECs at 24, 48, and 72 hours. Computed tomography (CT) and cardiac ultrasound were used to evaluate the position and heart rate of pacemakers 12 weeks after implantation, and the changes of plasma biochemical indexes were detected by a biochemical detector.
At 12 weeks after implantation, CT results showed that there were no changes in the position of the self-powered pacemaker. The device implanted into the thoracic cavity of rats demonstrated certain effects on cardiac function, while it did not have a significant effect on their blood biochemical indexes.
the flexible buckling piezoelectric vibratory energy collector did not produce adverse effects on the myocardial tissue or on the normal proliferation of myocardial cells.
通过能量转换装置，即植入式能量采集器，从生物力学运动中获取能量以获得可持续电能，是为需要长期持续供电的植入式医疗设备供电的理想方式。设计了一种新型自供电心脏起搏器以实现自供电起搏。心脏的动能由植入的压电能量采集器收集并供应给心脏起搏器，然后通过从心脏外部刺入的起搏电极刺激心脏组织，以实现有效的起搏效果和自供电起搏。在本研究中，我们评估了我们先前描述的柔性屈曲压电振动能量采集器的稳定性和生物相容性。通过进行细胞和动物实验，分析了制备的具有柔性屈曲压电振动能量采集装置的自供电起搏器的生物相容性、稳定性和安全性。
采用MTT（3-(4,5-二甲基噻唑-2-基)-2,5-二苯基四氮唑溴盐）法检测H9C2细胞和人脐静脉内皮细胞（HUVECs）在24、48和72小时的细胞增殖情况。植入12周后，采用计算机断层扫描（CT）和心脏超声评估起搏器的位置和心率，并通过生化检测仪检测血浆生化指标的变化。
植入12周后，CT结果显示自供电起搏器的位置无变化。植入大鼠胸腔的装置对心脏功能有一定影响，但对其血液生化指标无显著影响。
柔性屈曲压电振动能量采集器对心肌组织或心肌细胞的正常增殖未产生不良影响。
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