新冠病毒德尔塔变异株的传播事件揭示了多起疫苗突破性感染病例。
Transmission event of SARS-CoV-2 Delta variant reveals multiple vaccine breakthrough infections.
作者信息
Farinholt Timothy, Doddapaneni Harsha, Qin Xiang, Menon Vipin, Meng Qingchang, Metcalf Ginger, Chao Hsu, Gingras Marie-Claude, Farinholt Paige, Agrawal Charu, Muzny Donna M, Piedra Pedro A, Gibbs Richard A, Petrosino Joseph
机构信息
Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
出版信息
medRxiv. 2021 Jul 12:2021.06.28.21258780. doi: 10.1101/2021.06.28.21258780.
IMPORTANCE
Vaccine breakthrough by an emergent SARS-CoV-2 variant poses a great risk to global public health.
OBJECTIVE
To determine the SARS-CoV-2 variant responsible for 6 cases of vaccine breakthrough.
DESIGN
Nasopharyngeal swabs from suspected vaccine breakthrough cases were tested for SARS-CoV-2 by qPCR for Wuhan-Hu1 and Alpha variant. Positive samples were then sequenced by Swift Normalase Amplicon Panels to determine the causal variant.
SETTING
Transmission event occurred at events surrounding a wedding outside of Houston, TX. Two patients from India, likely transmitted the Delta variant to other guests.
PARTICIPANTS
Following a positive SARS-CoV-2 qPCR test at a third-party site, six fully vaccinated patients were investigated. Three males and three females ranged from 53 to 69 years old. One patient suffered from diabetes while three others were classified as overweight. No significant other comorbidities were identified. None of the patients had a history of failed vaccination.
重要性
新型严重急性呼吸综合征冠状病毒2（SARS-CoV-2）变种导致的疫苗突破对全球公共卫生构成巨大风险。
目的
确定导致6例疫苗突破病例的SARS-CoV-2变种。
设计
对疑似疫苗突破病例的鼻咽拭子进行检测，通过针对武汉-胡1和阿尔法变种的定量聚合酶链反应（qPCR）检测SARS-CoV-2。然后，对阳性样本使用Swift Normalase扩增子面板进行测序，以确定致病变种。
背景
传播事件发生在德克萨斯州休斯顿以外一场婚礼周边的活动中。两名来自印度的患者可能将德尔塔变种传播给了其他宾客。
参与者
在第三方检测点进行的SARS-CoV-2 qPCR检测呈阳性后，对6名完全接种疫苗的患者展开调查。其中3名男性和3名女性，年龄在53岁至69岁之间。1名患者患有糖尿病，另外3名被归类为超重。未发现其他显著的合并症。所有患者均无疫苗接种失败史。
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