Omuta City Zoo, 163 Showa-machi, Omuta, Fukuoka 836-0871, Japan.
Present address: Hitachi Kamine Zoo, 5-2-22 Miyatacho, Hitachi, Ibaraki 317-0055, Japan.
J Vet Med Sci. 2021 Sep 15;83(9):1454-1458. doi: 10.1292/jvms.21-0032. Epub 2021 Jul 19.
Lions (Panthera leo) breed well under captivity, so contraception has been commonly conducted for population management, leading to a demand for a less invasive and reversible contraceptive approach in lions. In this study, we examined the efficacy of a commercial gonadotropin-releasing hormone vaccine as a method of suppressing reproductive activity in a sexually matured female lion. Under behavioral restraint, the vaccine was injected twice (days 0 and 109). After the initial vaccination, ovarian activity is still observed. After the second vaccination, contraceptive effect was confirmed for 246 days until restart of estrous cycles. We confirmed only a slight swelling around the injection site after the second vaccination. This study may suggest an alternative option for a contraceptive method in lions.
狮子（ Panthera leo ）在圈养环境下繁殖良好，因此通常采用避孕措施来进行种群管理，这导致人们对一种对狮子更具侵入性和可逆性的避孕方法产生了需求。在这项研究中，我们研究了一种商业促性腺激素释放激素疫苗作为抑制性成熟雌性狮子生殖活动的方法的功效。在行为约束下，该疫苗分两次注射（第 0 天和第 109 天）。初次接种后，仍观察到卵巢活动。第二次接种后，避孕效果可维持 246 天，直到发情周期重新开始。我们仅在第二次接种后确认注射部位周围有轻微肿胀。这项研究可能为狮子的避孕方法提供了一种替代选择。
