Chouliaras Giorgos L, Krepis Panagiotis, Bouzios Ilias, Zellos Aglaia, Chrousos George, Roma-Giannikou Eleftheria
2nd Department of Pediatrics, University of Athens, "P & Ag. Kyriakou" Children's Hospital (Giorgos L. Chouliaras, Panagiotis Krepis).
1st Department of Pediatrics, University of Athens, "Aghia Sophia" Children's Hospital (Ilias Bouzios, Aglaia Zellos, George Chrousos, Eleftheria Roma-Giannikou), Athens, Greece.
Ann Gastroenterol. 2021 Jul-Aug;34(4):528-534. doi: 10.20524/aog.2021.0626. Epub 2021 Apr 3.
Functional constipation (FC) is the most common gastrointestinal disorder of childhood and has a multifactorial etiology. We aimed to assess dietary habits in Greek children with FC compared to the general population (control group, CG).
This was a subgroup analysis of a school-based, cross-sectional study carried out in children 6-18 years of age, between January and June 2014, using the Rome III criteria for the diagnosis of FC. Dietary parameters, as well as socioeconomic and demographic data and their association with the likelihood of FC, were analyzed through multivariate logistic regression analysis and expressed as odds ratios (OR).
A total of 1439 children (1218 CG, 221 FC) were included in the analysis. The final model showed that consumption of was the only dietary parameter significantly related to FC; higher frequency of consumption was inversely related to the likelihood of FC (OR: 0.98, 95% CI: 0.96, 0.99, P=0.048). Significant socioeconomic confounders with a positive association with FC were: parental educational level, victimization, physical activity and number of adults at home.
Increased frequency of fiber consumption is significantly associated with higher odds of FC irrespective of socioeconomic background and lifestyle parameters. Interventional studies are required to validate these cross-sectional observations.
功能性便秘（FC）是儿童期最常见的胃肠疾病，其病因具有多因素性。我们旨在评估与普通人群（对照组，CG）相比，希腊患功能性便秘儿童的饮食习惯。
这是一项基于学校的横断面研究的亚组分析，该研究于2014年1月至6月对6至18岁儿童进行，采用罗马III标准诊断功能性便秘。通过多因素逻辑回归分析饮食参数以及社会经济和人口统计学数据及其与功能性便秘可能性的关联，并以比值比（OR）表示。
共有1439名儿童（1218名对照组，221名功能性便秘组）纳入分析。最终模型显示，某种食物的摄入量是唯一与功能性便秘显著相关的饮食参数；较高的摄入频率与功能性便秘的可能性呈负相关（OR：0.98，95%可信区间：0.96，0.99，P = 0.048）。与功能性便秘呈正相关的显著社会经济混杂因素有：父母教育水平、受欺负情况、身体活动及家中成年人数量。
无论社会经济背景和生活方式参数如何，膳食纤维摄入频率增加都与功能性便秘的较高几率显著相关。需要进行干预性研究来验证这些横断面观察结果。
