Yamamoto M, Saito S, Sakurada T, Fukazawa H, Yoshida K, Kaise K, Kaise N, Nomura T, Itagaki Y, Yonemitsu K
Second Department of Internal Medicine, Tohoku University School of Medicine, Japan.
Clin Endocrinol (Oxf). 1987 Sep;27(3):339-44. doi: 10.1111/j.1365-2265.1987.tb01160.x.
Twelve patients with subacute thyroiditis were divided into two groups and treated with prednisolone or salicylate. The initially elevated T4, T3, free T4 (FT4), free T3 (FT3) and erythrocyte sedimentation rate (ESR) were reduced during the early phase within about 4 weeks in both groups. The serum levels of thyroglobulin (Tg) were elevated in both groups treated with salicylate and prednisolone (252 +/- SD 117 ng/ml and 233 +/- SD 157 ng/ml, respectively) at initial examination. The serum level of Tg declined during the early phase with prednisolone treatment, and it reached normal values at the end of the early phase (17 +/- SD 15 ng/ml). With salicylate treatment, the decline of levels of Tg was delayed and it was elevated (80 +/- SD 34 ng/ml) despite normal levels of thyroid hormones and ESR at the end of early phase. The serum level of Tg at the end of the early phase of prednisolone treated was significantly lower than that of salicylate treatment (P less than 0.01). It is suggested that the effect of prednisolone on rapid decrease of Tg may be related to its inhibitory action of intrathyroid hydrolysis.
12例亚急性甲状腺炎患者被分为两组，分别接受泼尼松龙或水杨酸盐治疗。两组患者最初升高的T4、T3、游离T4（FT4）、游离T3（FT3）和红细胞沉降率（ESR）在约4周的早期阶段均有所下降。在初始检查时，接受水杨酸盐和泼尼松龙治疗的两组患者血清甲状腺球蛋白（Tg）水平均升高（分别为252±标准差117 ng/ml和233±标准差157 ng/ml）。泼尼松龙治疗时，早期阶段血清Tg水平下降，在早期阶段结束时降至正常水平（17±标准差15 ng/ml）。水杨酸盐治疗时，Tg水平下降延迟，尽管在早期阶段结束时甲状腺激素和ESR水平正常，但Tg仍升高（80±标准差34 ng/ml）。泼尼松龙治疗早期阶段结束时的血清Tg水平显著低于水杨酸盐治疗（P<0.01）。提示泼尼松龙使Tg快速下降的作用可能与其对甲状腺内水解的抑制作用有关。
