Tajiri J, Noguchi S, Morita M, Tamaru M, Murakami T, Murakami N
Noguchi Thyroid Clinic and Hospital Foundation, Oita, Japan.
Endocr J. 1993 Feb;40(1):83-7. doi: 10.1507/endocrj.40.83.
To evaluate the usefulness of monitoring serum sialic acid (SA) levels for diagnosis and follow-up of subacute granulomatous thyroiditis (SAT), 43 patients were studied at our clinic. In the acute phase of the disease their SA levels averaged 104.9 +/- 19.7 mg/dl (normal 44-69 mg/dl). In the recovery phase SA levels returned to a range of 60.5 +/- 6.9 mg/dl. However, an increase in SA (87.4 +/- 18.2 mg/dl) was detected at the time of recurrence in 14 patients. In 29 non-recurrent patients, serum SA gradually reduced during the course of therapy and normalized in all patients by the time glucocorticoid therapy was discontinued. Thyroglobulin (Tg) and the erythrocyte sedimentation rate (ESR), however, had normalized in only half the cases even at the time of cessation of therapy (Tg 5/11, ESR 4/8). C-reactive protein (CRP) returned to negative in most patients (19/24) only one week after initiation of the therapy. These results suggested that the monitoring of SA levels can be a useful tool in diagnosis and follow-up of SAT.
为评估监测血清唾液酸（SA）水平对亚急性肉芽肿性甲状腺炎（SAT）诊断及随访的作用，我们门诊对43例患者进行了研究。疾病急性期患者的SA水平平均为104.9±19.7mg/dl（正常范围44 - 69mg/dl）。恢复期SA水平恢复至60.5±6.9mg/dl。然而，14例复发患者复发时SA水平升高（87.4±18.2mg/dl）。29例未复发患者血清SA在治疗过程中逐渐降低，所有患者在停用糖皮质激素治疗时恢复正常。然而，即便在治疗停止时，甲状腺球蛋白（Tg）和红细胞沉降率（ESR）仅在半数病例中恢复正常（Tg 5/11，ESR 4/8）。多数患者（19/24）在治疗开始仅1周后C反应蛋白（CRP）恢复阴性。这些结果提示，监测SA水平可能是SAT诊断及随访的一项有用工具。
