对……中……的遗传图谱绘制和表型分析。你提供的原文似乎不完整，“in”后面缺少具体内容。

Genetic mapping and phenotypic analysis of in .

作者信息

Talley Elyse M, Watts Charlie T, Aboyer Sonia, Adamson Madeline G, Akoto Harriet Ab, Altemus Haley, Avella Philip J, Bailey Rebecca, Bell Elizabeth R, Bell Katheryn L, Breneman Kelsey, Burkhart Jessica S, Chanley Logan J, Cook Savannah S, DesLaurier Mackenzie T, Dorsey Timothy R, Doyle Cassandra J, Egloff Merris E, Fasawe Ayoola S, Garcia Katy K, Graves Nathaniel P, Gray Tyler K, Gustafson Evan M, Hall Makayla J, Hayes Jaden D, Holic Lindsay J, Jarvis Brice A, Klos Piotr S, Kritzmire Sidney, Kuzovko Lera, Lainez Edwyna, McCoy Shamerra, Mierendorf James C, Neri Nicole A, Neville Caley R, Osborn Kelley, Parker Kaitlyn, Parks Megan E, Peck Kylee, Pitt Robyn, Platta Matthew E, Powell Brianna, Rodriguez Katalina, Ruiz Clara, Schaefer Mariah N, Shields Amanda B, Smiley Jasmine B, Stauffer Briona, Straub Devan, Sweeney John L, Termine Kaitlyn M, Thomas Brett, Toth Sophia D, Veile Taylor R, Walker Kayla S, Webster Paige N, Woodard Brian J, Yoder Quentin L, Young McKenzie K, Zeedyk McKenzie L, Ziegler Logan N, Bieser Kayla L, Puthoff David P, Stamm Joyce, Vrailas-Mortimer Alysia D, Kagey Jacob D, Merkle Julie A

机构信息

University of Evansville, Evansville, IN USA.

Illinois State University, Normal, IL USA.

出版信息

MicroPubl Biol. 2021 Jul 13;2021. doi: 10.17912/micropub.biology.000418. eCollection 2021.

DOI:10.17912/micropub.biology.000418

PMID:34278244

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8278230/

Abstract

Genetic screens are used to identify genes involved in specific biological processes. An EMS mutagenesis screen in identified growth control phenotypes in the developing eye. One mutant line from this screen, , was phenotypically characterized using the FLP/FRT system and genetically mapped by complementation analysis and genomic sequencing by undergraduate students participating in the multi-institution Fly-CURE consortium. was found to have a nonsense mutation in (), anortholog of the mammalian spectraplakin (). and are involved in cytoskeletal organization and play roles during cell growth and proliferation.

摘要

遗传筛选用于识别参与特定生物学过程的基因。一项在[具体内容未给出]中进行的EMS诱变筛选鉴定出了发育中的眼睛中的生长控制表型。来自该筛选的一个突变系[具体名称未给出]，使用FLP/FRT系统进行了表型特征分析，并由参与多机构Fly-CURE联盟的本科生通过互补分析和基因组测序进行了遗传定位。发现[具体名称未给出]在[具体基因名称未给出]（）中存在无义突变，该基因是哺乳动物光谱丝动蛋白[具体基因名称未给出]（）的直系同源物。[具体基因名称未给出]和[具体基因名称未给出]参与细胞骨架组织，并在细胞生长和增殖过程中发挥作用。