使用I-TASSER注释假定蛋白质。

Annotating Putative Proteins Using I-TASSER.

作者信息

McCullough Jacquelyn, Fey Petra, Rahman Ryan J, Wallace Morgan, Morey Seeta, Sahlberg Kyle, McGonagle Ethan, Hess Danielle, Hatfield Chance, Sarmiento Michaela-Romina, Velasquez Jordi, Gomer Richard H

机构信息

Department of Biology, Texas A&M University.

Center for Genetic Medicine, Northwestern University.

出版信息

MicroPubl Biol. 2021 Jul 14;2021. doi: 10.17912/micropub.biology.000420. eCollection 2021.

DOI:10.17912/micropub.biology.000420

PMID:34278246

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8280847/

Abstract

Using Gene Ontology annotation in any aspect or using any evidence code, we found that approximately 14% percent of predicted proteins have no GO annotations and no obvious similarity to any annotated protein across diverse organisms. We have been systematically examining these unannotated protein sequences using software that predicts a protein structure and then compares the predicted structure to known structures.

摘要

在任何方面使用基因本体注释或使用任何证据代码，我们发现，预测的蛋白质中约有14%没有基因本体注释，并且与不同生物体中任何已注释的蛋白质没有明显的相似性。我们一直在使用预测蛋白质结构然后将预测结构与已知结构进行比较的软件，系统地研究这些未注释的蛋白质序列。