Yoshida Keisuke, Fujita Shin-Ichiro, Isotani Ayako, Kudo Takashi, Takahashi Satoru, Ikawa Masahito, Shiba Dai, Shirakawa Masaki, Muratani Masafumi, Ishii Shunsuke
RIKEN Cluster for Pioneering Research, Tsukuba, Ibaraki 305-0074, Japan.
Department of Genome Biology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
iScience. 2021 Jun 25;24(7):102773. doi: 10.1016/j.isci.2021.102773. eCollection 2021 Jul 23.
As space travel becomes more accessible, it is important to understand the effects of spaceflight including microgravity, cosmic radiation, and psychological stress. However, the effect on offspring has not been well studied in mammals. Here we investigated the effect of 35 days spaceflight on male germ cells. Male mice that had experienced spaceflight exhibit alterations in binding of transcription factor ATF7, a regulator of heterochromatin formation, on promoter regions in testis, as well as altered small RNA expression in spermatozoa. Offspring of space-traveling males exhibit elevated hepatic expression of genes related to DNA replication. These results indicate that spaceflight has intergenerational effect.
随着太空旅行变得更加可行，了解太空飞行的影响非常重要，这些影响包括微重力、宇宙辐射和心理压力。然而，太空飞行对哺乳动物后代的影响尚未得到充分研究。在此，我们研究了35天太空飞行对雄性生殖细胞的影响。经历过太空飞行的雄性小鼠在睾丸启动子区域表现出转录因子ATF7（异染色质形成的调节因子）结合的改变，以及精子中小RNA表达的改变。太空旅行雄性小鼠的后代肝脏中与DNA复制相关的基因表达升高。这些结果表明太空飞行具有代际效应。
