Department of Gastroenterology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, P.R. China.
The Fourth Department of the Digestive Disease Center, Suining Central Hospital, Suining, Sichuan 629000, P.R. China.
Mol Med Rep. 2021 Sep;24(3). doi: 10.3892/mmr.2021.12269. Epub 2021 Jul 19.
Digestive system malignant tumors are common tumors, and the traditional treatment methods for these tumors include surgical resection, radiotherapy, chemotherapy, and molecularly targeted drugs. However, diagnosis remains challenging, and the early detection of postoperative recurrence is complicated. Therefore, it is necessary to explore novel biomarkers to facilitate clinical diagnosis and treatment. Accumulating evidence supports the crucial role of chloride channels in the development of multiple types of cancers. Given that chloride channels are widely expressed and involved in cell proliferation, apoptosis and cell cycle, among other processes, they may serve as a promising diagnostic and therapeutic target. Chloride intracellular channels (CLICs) are a class of chloride channels that are upregulated or downregulated in certain types of cancer. Furthermore, in certain cases, during cell cycle progression, the localization and function of the cytosolic form of the transmembrane proteins of CLICs are also altered, which may provide a key target for cancer therapy. The aim of the present review was to focus on CLICs as biomarkers for digestive system tumors.
消化系统恶性肿瘤是常见的肿瘤，这些肿瘤的传统治疗方法包括手术切除、放疗、化疗和分子靶向药物。然而，诊断仍然具有挑战性，术后复发的早期检测较为复杂。因此，有必要探索新的生物标志物，以方便临床诊断和治疗。越来越多的证据支持氯离子通道在多种类型癌症的发展中起着关键作用。鉴于氯离子通道广泛表达，并参与细胞增殖、凋亡和细胞周期等过程，它们可能成为有前途的诊断和治疗靶点。氯离子细胞内通道（CLICs）是一类氯离子通道，在某些类型的癌症中上调或下调。此外，在某些情况下，在细胞周期进程中，CLICs 的跨膜蛋白的细胞质形式的定位和功能也会发生改变，这可能为癌症治疗提供一个关键的靶点。本综述的目的是重点关注 CLICs 作为消化系统肿瘤的生物标志物。
