Chen W J, Mo S T, Yu L J, Chen K M
Department of Surgery, College of Medicine, National Taiwan University, Taipei, ROC.
Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi. 1987 Aug;20(3):198-203.
Effects of exogenous fat emulsion (Intralipid) on lymphocyte function were studied, in vivo, with rats. Abdominal sepsis was induced in Sprague Dawley rats by cecal ligation and puncture. Following a bolus infusion of the fat emulsion or normal saline, lymphocyte proliferations after stimulation with bacto-concanavalin A (Con A), phytohemagglutinin (PHA), and pokeweed mitogen (PWM) were evaluated in animals divided into the following groups: group I, non-septic rats receiving saline infusion (NS-S); group II, non-septic rats receiving the fat emulsion (NS-F); group III, septic rats receiving saline (S-S); group IV, septic rats receiving the fat emulsion (S-F). Results of the study demonstrated that lymphocyte function was not suppressed by the presence of sepsis, and infusion of the exogenous fat emulsion also did not lead to a suppression of the lymphocyte function in either the septic or the non-septic rats. The results obtained from a previous, as well as this present, study suggest that although infusion of exogenous fat emulsion may suppress the function of monocyte and polymorphonuclear cells, lymphocyte function is not affected.
在大鼠体内研究了外源性脂肪乳剂（英脱利匹特）对淋巴细胞功能的影响。通过盲肠结扎和穿刺在斯普拉格-道利大鼠中诱发腹部脓毒症。在给予脂肪乳剂或生理盐水大剂量输注后，对分为以下几组的动物用细菌刀豆球蛋白A（伴刀豆球蛋白A）、植物血凝素（PHA）和商陆有丝分裂原（PWM）刺激后的淋巴细胞增殖进行评估：第一组，接受生理盐水输注的非脓毒症大鼠（NS-S）；第二组，接受脂肪乳剂的非脓毒症大鼠（NS-F）；第三组，接受生理盐水的脓毒症大鼠（S-S）；第四组，接受脂肪乳剂的脓毒症大鼠（S-F）。研究结果表明，脓毒症的存在并未抑制淋巴细胞功能，并且外源性脂肪乳剂的输注在脓毒症或非脓毒症大鼠中均未导致淋巴细胞功能受到抑制。从前一项以及本项研究中获得的结果表明，尽管外源性脂肪乳剂的输注可能会抑制单核细胞和多形核细胞的功能，但淋巴细胞功能不受影响。
