Chen W J, Yu L J, Mo S T
Department of Surgery, National Taiwan University Hospital, Taipei, Republic of China.
Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi. 1990 Nov;23(4):271-6.
The effect of exogenous fat emulsion on phagocytic activity of polymorphonuclear (PMN) cells in sepsis was studied in rats. The rats were divided into four groups. Group I, non-septic rats received saline infusion; group II, non-septic rats received exogenous fat emulsion; group III, septic rats received saline infusion; and group IV, septic rats received exogenous fat emulsion. Twenty hours after operation to induce sepsis, normal saline or exogenous fat emulsion was injected. Two hours later, the animal was sacrificed and the blood harvested. PMN cells were isolated from the blood, and phagocytic activity of the cells was studied by culture with Candida albicans. The results revealed that although sepsis led to a suppression of phagocytic function of PMN cells, infusion of exogenous fat emulsion had no deterious effect on the cell phagocytic activity in either septic or non-septic rats.
研究了外源性脂肪乳剂对脓毒症大鼠多形核（PMN）细胞吞噬活性的影响。将大鼠分为四组。第一组，非脓毒症大鼠输注生理盐水；第二组，非脓毒症大鼠输注外源性脂肪乳剂；第三组，脓毒症大鼠输注生理盐水；第四组，脓毒症大鼠输注外源性脂肪乳剂。诱导脓毒症手术后20小时，注射生理盐水或外源性脂肪乳剂。两小时后，处死动物并采集血液。从血液中分离出PMN细胞，通过与白色念珠菌共培养研究细胞的吞噬活性。结果显示，尽管脓毒症导致PMN细胞吞噬功能受到抑制，但外源性脂肪乳剂的输注对脓毒症或非脓毒症大鼠的细胞吞噬活性均无有害影响。
