乙型肝炎表面基因及乙肝病毒增强子元件的核苷酸序列特征分析

Characterization of nucleotide sequence of hepatitis B surface gene and enhancer element of HBV.

作者信息

Ting L P, Chang H K

机构信息

Graduate Institute of Microbiology and Immunology, National Yang-Ming Medical College, Taipei, ROC.

出版信息

Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi. 1987 Aug;20(3):224-40.

PMID:3428015

Abstract

The HBV DNA sequence containing a primary part of pre-S2, the coding sequence of the major S protein and the enhancer sequence in pTWS1 was completely sequenced. A comparison with other previously published HBV sequences indicates that the nucleotide sequence homology in the pre-S2 region is 97%, 98% and 98% for adw, adr and ayw subtypes, respectively, and 76% among different subtypes. The nucleotide sequence homology in the major S protein region is 99% for each adw, adr and ayw subtype, and 90% among different subtypes. The important regulatory enhancer sequence (nucleotides 1036-1204) is identical in all subtypes.

摘要

对pTWS1中包含前S2主要部分、主要S蛋白编码序列和增强子序列的乙肝病毒（HBV）DNA序列进行了全序列测定。与其他先前发表的HBV序列比较表明，前S2区核苷酸序列同源性在adw、adr和ayw亚型中分别为97%、98%和98%，不同亚型间为76%。主要S蛋白区核苷酸序列同源性在各adw、adr和ayw亚型中均为99%，不同亚型间为90%。重要的调控增强子序列（核苷酸1036 - 1204）在所有亚型中均相同。