Ono Y, Onda H, Sasada R, Igarashi K, Sugino Y, Nishioka K
Nucleic Acids Res. 1983 Mar 25;11(6):1747-57. doi: 10.1093/nar/11.6.1747.
The complete nucleotide sequences of two different subtypes (adr and adw) of hepatitis B virus (HBV) DNA cloned in E. coli were determined. The sequence of the viral genome of the adr clone was 3188 nucleotides long, and that of the adw clone was 3200 nucleotides long. The adr and adw clones differed from the reported cloned ayw HBV DNA (3182 nucleotides long) in 11.2% and 10.0% of nucleotides, respectively. Heterogeneity of the HBV genome in the clones with the same subtype was observed.
测定了克隆于大肠杆菌中的两种不同亚型（adr和adw）的乙型肝炎病毒（HBV）DNA的完整核苷酸序列。adr克隆的病毒基因组序列长度为3188个核苷酸，adw克隆的病毒基因组序列长度为3200个核苷酸。adr和adw克隆与已报道的克隆ayw HBV DNA（长度为3182个核苷酸）相比，核苷酸差异分别为11.2%和10.0%。在相同亚型的克隆中观察到HBV基因组的异质性。
