Univ Angers, Inserm, CNRS, MINT, SFR ICAT, F-49000 Angers, France; Univ Angers, PRISM, SFR ICAT, F-49000 Angers, France.
Univ Angers, Inserm, CNRS, MINT, SFR ICAT, F-49000 Angers, France.
J Control Release. 2021 Sep 10;337:155-167. doi: 10.1016/j.jconrel.2021.07.025. Epub 2021 Jul 16.
Nuclear Magnetic Resonance (NMR) based diffusion methods open new perspectives for nanomedicine characterization and their bioenvironment interaction understanding. This review summarizes the theoretical background of diffusion phenomena. Self-diffusion and mutual diffusion coefficient notions are featured. Principles, advantages, drawbacks, and key challenges of NMR diffusometry spectroscopic and imaging methods are presented. This review article also gives an overview of representative applicative works to the nanomedicine field that can contribute to elucidate important issues. Examples of in vitro characterizations such as identification of formulated species, process monitoring, drug release follow-up, nanomedicine interactions with biological barriers are presented as well as possible transpositions for studying in vivo nanomedicine fate.
基于核磁共振（NMR）的扩散方法为纳米医学特性表征及其生物环境相互作用的理解开辟了新的视角。本综述总结了扩散现象的理论背景。重点介绍了自扩散和互扩散系数的概念。介绍了 NMR 扩散光谱学和成像方法的原理、优点、缺点和关键挑战。本文还概述了纳米医学领域有代表性的应用工作，这些工作有助于阐明重要问题。介绍了体外特性研究的实例，如配方物种的鉴定、过程监测、药物释放跟踪、纳米医学与生物屏障的相互作用，以及用于研究体内纳米医学命运的可能转化。
