Institute of Legal Medicine, University Hospital, Goethe University, Frankfurt/Main, Germany.
Institute of Legal Medicine, University Hospital, Goethe University, Frankfurt/Main, Germany.
Forensic Sci Int. 2021 Aug;325:110905. doi: 10.1016/j.forsciint.2021.110905. Epub 2021 Jul 10.
In cases of drunk-driving, allegations that alcohol has been consumed after the incident, are proved by analyzing congener alcohols in the blood sample. 1-Propanol, one of the main congener compounds, was tested, whether it is also endogenously formed when a person has consumed alcoholic beverages.
Eleven male and 13 female volunteers consumed congener-free vodka (37.5 vol% ethanol, individual doses: 0.15-0.32 l) within one hour. Blood samples were taken up to 10 h and analyzed for ethanol and congener alcohols by headspace gas chromatography-mass spectrometry.
Ethanol concentrations reached in blood a maximum of 0.65-1.23 g/l and decreased by 0.18 g/l/h (median values). Of the congener alcohols analyzed, only methanol and 1-propanol were detected in the plasma samples of all subjects. The endogenous methanol concentration increased from 0.66 mg/l by 0.22 mg/l/h to 2.19 mg/l (medians). 1-Propanol was not detected prior to alcohol consumption. Maximum concentrations of 0.10-0.32 mg/L were measured after 1.0-4.5 h. A plateau of the 1-propanol concentration was observed in the plasma samples of the 18 subjects lasting for 0.5-4.0 h and this alcohol was completely eliminated at ethanol concentrations of 0.17 g/l (median, range 0.03-0.55 g/l).
The results of the study confirm the formation of 1-propanol after consumption of 1-propanol-free beverages, which should be taken into account when evaluating its concentration.
在酒后驾车的情况下，通过分析血液样本中的同系醇来证明事发后是否摄入了酒精。本文测试了 1-丙醇，这是主要的同系醇化合物之一，当一个人摄入酒精饮料时，它是否也是内源性形成的。
11 名男性和 13 名女性志愿者在一小时内饮用无同系醇的伏特加（37.5%乙醇，个体剂量：0.15-0.32 升）。采血时间长达 10 小时，并通过顶空气相色谱-质谱法分析乙醇和同系醇。
血液中的乙醇浓度最高达到 0.65-1.23g/l，并以 0.18g/l/h 的速度下降（中位数）。在所分析的同系醇中，只有甲醇和 1-丙醇在所有受试者的血浆样本中被检测到。内源性甲醇浓度从 0.66mg/l 增加到 0.22mg/l/h 至 2.19mg/l（中位数）。在饮酒前未检测到 1-丙醇。在 1.0-4.5 小时后测量到 0.10-0.32mg/L 的最大浓度。在 18 名受试者的血浆样本中观察到 1-丙醇浓度的平台期，持续 0.5-4.0 小时，当乙醇浓度为 0.17g/l（中位数，范围 0.03-0.55g/l）时，1-丙醇完全消除。
研究结果证实了饮用无 1-丙醇饮料后 1-丙醇的形成，在评估其浓度时应考虑这一点。
