CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China; School of Public Health, Shandong University, Jinan 250000, Shandong Province, China.
Department of Neuro-onoclogy, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
J Colloid Interface Sci. 2021 Dec 15;604:596-603. doi: 10.1016/j.jcis.2021.07.004. Epub 2021 Jul 6.
In view of the photothermal effect of polydopamine (PDA) nanoparticles and their internal D-π-D structures during assembly, the two-photon excited properties of PDA were studied toward the biomedical application. Further, the PDA molecules were coordinated with Mn and the assembled nanoparticles were covered by cancer cell membranes, the complex system could be used directly for the treatment of cancer with photothermal and chemodynamic therapy.
The two-photon excited PDA-Mn nanoparticles were used for the photothermal therapy combined with chemodynamic therapy. The complexes were coated with cancer cell membranes in order to enhance the tumor homologous efficiency. Multi-modal bioimaging and anti-tumor detections were carried out both in vitro and in vivo.
PDA nanoparticles were demonstrated to have both good two-photon excited fluorescence and photothermal efficiency. The assembled nanoparticles modified with Mn and cancer cell membranes have an obvious targeting and synergetic anti-cancer efficiency. The system creates a simple way for a precise operation with multi-modal imaging function.
鉴于聚多巴胺（PDA）纳米粒子在组装过程中的光热效应及其内部 D-π-D 结构，研究了 PDA 的双光子激发特性，以期将其应用于生物医学领域。此外，将 PDA 分子与 Mn 配位，并用癌细胞膜覆盖组装的纳米粒子，该复合体系可直接用于光热和化学动力学治疗癌症。
用双光子激发的 PDA-Mn 纳米粒子进行光热治疗联合化学动力学治疗。为了提高肿瘤同源效率，将复合物包裹在癌细胞膜中。在体外和体内进行了多模态生物成像和抗肿瘤检测。
证明 PDA 纳米粒子具有良好的双光子激发荧光和光热效率。用 Mn 和癌细胞膜修饰的组装纳米粒子具有明显的靶向和协同抗癌效果。该体系为具有多模态成像功能的精确操作创造了一种简单的方法。
