Kanaley J A, Boileau R A, Bahr J A, Misner J E, Nelson R A
Department of Kinesiology, Animal Sciences and Internal Medicine, University of Illinois, Champaign 61801.
Med Sci Sports Exerc. 1992 Aug;24(8):873-80.
The purpose of this study was to determine the extent to which growth hormone (GH) and energy substrate utilization are influenced by basal sex steroid levels during prolonged submaximal exercise across menstrual phase and status. Also the 17 beta-estradiol (E2) and progesterone responses during prolonged exercise were compared according to menstrual phase and menstrual status. Six amenorrheic (AMc) athletes and seven eumenorrheic (EUc) athletes ran at 60% VO2max for 90 min and serial blood samples were taken at rest, every 10 min throughout exercise, and 5 and 15 min post-exercise. The EUc athletes were tested in the early follicular phase (EF) (days 3-5), the late follicular phase (LF) (days 14-16) and the mid-luteal phase (ML) (days 22-25). The incremental GH response to exercise, measured by area under the curve, was consistent with previous reposts and was not altered according to menstrual phase or status (EF-37.5 +/- 11.5, LF-61.9 +/- 11.5, ML-48.1 +/- 12.8 micrograms.1-1.90 min-1). Furthermore, carbohydrate and fat utilization during exercise were not influenced by basal sex steroid levels associated with menstrual phase or status. The incremental E2 response to exercise in AMc athletes was significantly smaller than seen in EUc athletes (AMc-208.1 +/- 44.0, EF-383.0 +/- 116.4, LF-204.7 +/- 84.1, ML-45.1 +/- 18.4 pmol.1(-1).90 min-1), although the pattern of release is similar between groups. In conclusion, GH levels and substrate utilization are independent of both menstrual phase and status; hence, menstrual phase has no negative ramifications on metabolism during exercise. Amenorrhea does not result in metabolic consequences during prolonged exercise by influencing substrate utilization.
本研究的目的是确定在整个月经周期和月经状态下进行长时间次最大运动期间，生长激素（GH）和能量底物利用受基础性激素水平影响的程度。此外，还根据月经周期和月经状态比较了长时间运动期间17β-雌二醇（E2）和孕酮的反应。六名闭经（AMc）运动员和七名月经正常（EUc）运动员以60%的最大摄氧量（VO2max）跑90分钟，并在静息时、运动全程每10分钟、运动后5分钟和15分钟采集系列血样。EUc运动员在卵泡早期（EF）（第3 - 5天）、卵泡晚期（LF）（第14 - 16天）和黄体中期（ML）（第22 - 25天）接受测试。通过曲线下面积测量的运动后GH增量反应与先前报告一致，且不受月经周期或状态影响（EF - 37.5±11.5、LF - 61.9±11.5、ML - 48.1±12.8微克·升-1·90分钟-1）。此外，运动期间碳水化合物和脂肪的利用不受与月经周期或状态相关的基础性激素水平影响。AMc运动员运动后E2的增量反应明显小于EUc运动员（AMc - 208.1±44.0、EF - 383.0±116.4、LF - 204.7±84.1、ML - 45.1±18.4皮摩尔·升-1·90分钟-1），尽管两组间释放模式相似。总之，GH水平和底物利用与月经周期和月经状态均无关；因此，月经周期对运动期间的代谢没有负面影响。闭经在长时间运动期间不会通过影响底物利用而导致代谢后果。
