Yang Rui-Bo, Wu Li-Ping, Lu Xiao-Xiao, Zhang Chen, Liu Hui, Huang Yue, Jia Zhe, Gao Yi-Chen, Zhao Shao-Zhen
Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China.
Int J Ophthalmol. 2021 Jul 18;14(7):1100-1106. doi: 10.18240/ijo.2021.07.20. eCollection 2021.
Fungal keratitis (FK) is a refractory disease that poses a serious threat to vision, with common risk factors like eye trauma, contact lens wearing, topical corticosteroids and antibiotic abuse. Nowadays, topical and systemic anti-fungal drugs and ocular surgeries are still the main therapeutic modalities. However, the pathogenesis of FK, especially the immunologic mechanism within it, has not yet been deeply clarified. A better understanding of the pathogenesis of FK is imperative for more effective therapies and prognosis. Meanwhile, the immune protection strategies are also urgently required to manage FK. This review highlights recent advances in the immunologic mechanism in the pathogenesis of FK, in hope of providing valuable reference information for more effective anti-fungal treatment.
真菌性角膜炎（FK）是一种对视力构成严重威胁的难治性疾病，常见危险因素包括眼外伤、佩戴隐形眼镜、局部使用皮质类固醇和滥用抗生素。目前，局部和全身抗真菌药物以及眼科手术仍是主要治疗方式。然而，FK的发病机制，尤其是其中的免疫机制，尚未得到深入阐明。更好地了解FK的发病机制对于更有效的治疗和预后至关重要。同时，管理FK也迫切需要免疫保护策略。本综述重点介绍了FK发病机制中免疫机制的最新进展，希望为更有效的抗真菌治疗提供有价值的参考信息。
