朊病毒木马和隧道纳米管可使帕金森病中α-突触核蛋白病变扩散。
Trojan horses and tunneling nanotubes enable α-synuclein pathology to spread in Parkinson disease.
机构信息
Department of Biochemistry & Molecular Biology, Louisiana State University Health Sciences Center, United States of America.
出版信息
PLoS Biol. 2021 Jul 20;19(7):e3001331. doi: 10.1371/journal.pbio.3001331. eCollection 2021 Jul.
Abstract
In Parkinson disease (PD), Lewy bodies (LBs) form in the gut or nose and spread into the midbrain. A study in this issue indicates that the spread is due to lysosomes "infected" with prion-like alpha-synuclein (α-syn) transmitting from cell to cell via tunneling nanotubes (TNTs).
摘要
在帕金森病（PD）中，路易体（LB）形成于肠道或鼻腔，并扩散到中脑。本期的一项研究表明，这种扩散是由于溶酶体“感染”了朊病毒样的α-突触核蛋白（α-syn），通过隧道纳米管（TNTs）在细胞间传递。
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