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朊病毒木马和隧道纳米管可使帕金森病中α-突触核蛋白病变扩散。

Trojan horses and tunneling nanotubes enable α-synuclein pathology to spread in Parkinson disease.

机构信息

Department of Biochemistry & Molecular Biology, Louisiana State University Health Sciences Center, United States of America.

出版信息

PLoS Biol. 2021 Jul 20;19(7):e3001331. doi: 10.1371/journal.pbio.3001331. eCollection 2021 Jul.

DOI:10.1371/journal.pbio.3001331
PMID:34284485
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8291968/
Abstract

In Parkinson disease (PD), Lewy bodies (LBs) form in the gut or nose and spread into the midbrain. A study in this issue indicates that the spread is due to lysosomes "infected" with prion-like alpha-synuclein (α-syn) transmitting from cell to cell via tunneling nanotubes (TNTs).

摘要

在帕金森病（PD）中，路易体（LB）形成于肠道或鼻腔，并扩散到中脑。本期的一项研究表明，这种扩散是由于溶酶体“感染”了朊病毒样的α-突触核蛋白（α-syn），通过隧道纳米管（TNTs）在细胞间传递。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df0a/8291968/fed16f432c28/pbio.3001331.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df0a/8291968/fed16f432c28/pbio.3001331.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df0a/8291968/fed16f432c28/pbio.3001331.g001.jpg

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Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease.肠道到大脑的病理性 α-突触核蛋白的转神经元传播可模拟帕金森病。
Neuron. 2019 Aug 21;103(4):627-641.e7. doi: 10.1016/j.neuron.2019.05.035. Epub 2019 Jun 26.
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Correlative cryo-electron microscopy reveals the structure of TNTs in neuronal cells.
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