Hug Eugen B, Pelak Maciej, Frank Steven J, Fossati Piero
MedAustron Ion Therapy Center, Wiener Neustadt, Austria.
MD Anderson Cancer Center, Division of Radiation Oncology, Houston, TX, USA.
Int J Part Ther. 2021 Jun 25;8(1):168-178. doi: 10.14338/IJPT-20-00083. eCollection 2021 Summer.
Skull base tumors constitute one of the established indications for particle therapy, specifically proton therapy. However, a number of prognostic factors, practical clinical management issues, and the emerging role of carbon ion therapy remain subjects of active clinical investigation. This review summarizes these topics, assesses the present status, and reflects on future research directions focusing on the management of chordomas, one of the most aggressive skull base tumors. In addition, the role of particle therapy for benign tumors of the skull base, including pituitary adenoma and acoustic neuroma, is reviewed.
颅底肿瘤是粒子治疗(特别是质子治疗)已确定的适应症之一。然而,一些预后因素、实际临床管理问题以及碳离子治疗的新兴作用仍是积极临床研究的主题。本综述总结了这些主题,评估了当前状况,并思考了针对脊索瘤(最具侵袭性的颅底肿瘤之一)治疗的未来研究方向。此外,还综述了粒子治疗在颅底良性肿瘤(包括垂体腺瘤和听神经瘤)中的作用。