Department of Biological Sciences, Hyupsung University, Hwasung-si, 18330, Korea.
Chem Commun (Camb). 2021 Aug 5;57(63):7731-7742. doi: 10.1039/d1cc02168k.
Over the past ten years, advances in the field of organelle-targeted photothermal therapy (PTT) have stimulated the rapid development of organelle-targeted PTT agents as anticancer therapeutic agents. However, to the best of our knowledge, no comprehensive review of organelle-targeted PTT agents has been reported thus far. In this article, we have provided a structured approach for describing the different types and properties of each organelle-targeted PTT agent as well as the potential future therapeutic applications that were classified by their target organelles. Representative agents that have been used in the field of PTT since 2010 have been summarized and the most recent advances in improving the therapeutic efficacy across various types of cancers have also been highlighted.
在过去的十年中，细胞器靶向光热治疗（PTT）领域的进展刺激了细胞器靶向 PTT 剂作为抗癌治疗剂的快速发展。然而，据我们所知，迄今为止，尚无关于细胞器靶向 PTT 剂的全面综述。在本文中，我们提供了一种结构化的方法来描述每种细胞器靶向 PTT 剂的不同类型和特性，以及按其靶向细胞器分类的潜在未来治疗应用。总结了自 2010 年以来在 PTT 领域中使用的代表性试剂，并强调了提高各种类型癌症治疗效果的最新进展。
