奥沙拉嗪对溃疡性结肠炎患者胃肠转运的影响。
Influence of olsalazine on gastrointestinal transit in ulcerative colitis.
作者信息
Rao S S, Read N W, Holdsworth C D
机构信息
Gastrointestinal Unit, Royal Hallamshire Hospital, Sheffield, UK.
出版信息
Gut. 1987 Nov;28(11):1474-7. doi: 10.1136/gut.28.11.1474.
Abstract
The effect of olsalazine on stool output and the transit of a solid radiolabelled meal through the stomach, small intestine and colon was studied in six patients with ulcerative colitis intolerant of sulphasalazine. Olsalazine 250 mg four times daily significantly accelerated gastric emptying (mean +/- SD; 45.3 +/- 24.2 min v 67.3 +/- 33.1 min, p less than 0.05), mouth to caecum transit time (242 +/- 41 min v 325 +/- 33 min, p less than 0.02) and whole gut transit time (60.5 +/- 26 h v 37.8 +/- 17.8 h, p less than 0.05). No significant changes were seen in mean daily stool weight (215 +/- 41 g v 162 +/- 62 g) and mean daily stool frequency (2.2 +/- 0.6 v 2.4 +/- 1.8). None of these patients developed diarrhoea, but acceleration of gastric and intestinal transit may be responsible for the diarrhoea reported in some patients taking this drug.
摘要
在6例对柳氮磺胺吡啶不耐受的溃疡性结肠炎患者中，研究了奥沙拉嗪对粪便排出量以及固体放射性标记餐通过胃、小肠和结肠的转运的影响。奥沙拉嗪每日4次，每次250mg，显著加快了胃排空（平均值±标准差；45.3±24.2分钟对67.3±33.1分钟，p<0.05）、口腔至盲肠转运时间（242±41分钟对325±33分钟，p<0.02）和全肠道转运时间（60.5±26小时对37.8±17.8小时，p<0.05）。平均每日粪便重量（215±41g对162±62g）和平均每日排便频率（2.2±0.6对2.4±1.8）未见显著变化。这些患者均未出现腹泻，但胃和肠道转运加快可能是一些服用该药物的患者报告出现腹泻的原因。
相似文献
1
Influence of olsalazine on gastrointestinal transit in ulcerative colitis.奥沙拉嗪对溃疡性结肠炎患者胃肠转运的影响。
Gut. 1987 Nov;28(11):1474-7. doi: 10.1136/gut.28.11.1474.
2
Studies on the mechanism of bowel disturbance in ulcerative colitis.溃疡性结肠炎肠道紊乱机制的研究。
Gastroenterology. 1987 Nov;93(5):934-40. doi: 10.1016/0016-5085(87)90554-3.
3
Olsalazine and GI transit in UC.奥沙拉嗪与溃疡性结肠炎的胃肠道转运
Gut. 1988 May;29(5):695-6. doi: 10.1136/gut.29.5.695-a.
4
Double-blind dose-finding study of olsalazine versus sulphasalazine as maintenance therapy for ulcerative colitis.奥沙拉嗪与柳氮磺胺吡啶作为溃疡性结肠炎维持治疗的双盲剂量探索性研究。
Eur J Gastroenterol Hepatol. 1995 May;7(5):391-6.
5
Disposition of 5-aminosalicylic acid from 5-aminosalicylic acid-delivering drugs during accelerated intestinal transit in healthy volunteers.健康志愿者在肠道加速转运过程中5-氨基水杨酸递送药物中5-氨基水杨酸的处置情况。
Scand J Gastroenterol. 1989 Dec;24(10):1179-85. doi: 10.3109/00365528909090784.
6
Olsalazine or sulphasalazine in first attacks of ulcerative colitis? A double blind study.奥沙拉嗪或柳氮磺胺吡啶用于溃疡性结肠炎初发发作？一项双盲研究。
Gut. 1989 May;30(5):675-9. doi: 10.1136/gut.30.5.675.
7
Effect of cisapride on the gastrointestinal transit of a solid meal in normal human subjects.西沙必利对正常人体固体食物胃肠转运的影响。
Gut. 1987 Jan;28(1):13-6. doi: 10.1136/gut.28.1.13.
8
Olsalazine versus sulphasalazine for relapse prevention in ulcerative colitis: a multicenter study.奥沙拉嗪与柳氮磺胺吡啶预防溃疡性结肠炎复发的多中心研究
Am J Gastroenterol. 1995 Mar;90(3):381-7.
9
Mebeverine decreases mass movements and stool frequency in lactulose-induced diarrhoea.美贝维林可减少乳果糖诱导腹泻中的集团蠕动和排便频率。
Aliment Pharmacol Ther. 1998 Jun;12(6):583-8. doi: 10.1046/j.1365-2036.1998.00340.x.
10
Ficus carica aqueous extract alleviates delayed gastric emptying and recovers ulcerative colitis-enhanced acute functional gastrointestinal disorders in rats.石榴皮水提物可缓解延迟排空胃和恢复溃疡性结肠炎增强的急性功能性胃肠疾病在大鼠。
J Ethnopharmacol. 2018 Oct 5;224:242-249. doi: 10.1016/j.jep.2018.06.001. Epub 2018 Jun 2.
引用本文的文献
1
Constipation in ulcerative colitis: pathophysiology and practical management.溃疡性结肠炎中的便秘：病理生理学与实际管理
Frontline Gastroenterol. 2020 Aug 26;12(6):493-499. doi: 10.1136/flgastro-2020-101566. eCollection 2021.
2
Current perspectives on the diagnosis and management of functional anorectal disorders in patients with inflammatory bowel disease.炎症性肠病患者功能性肛门直肠疾病诊断与管理的当前观点
Therap Adv Gastroenterol. 2018 Dec 6;11:1756284818816956. doi: 10.1177/1756284818816956. eCollection 2018.
3
Drug-induced gastrointestinal disorders.药物性胃肠疾病
Frontline Gastroenterol. 2014 Jan;5(1):49-57. doi: 10.1136/flgastro-2013-100316. Epub 2013 Jun 19.
4
Aminosalicylates for induction of remission or response in Crohn's disease.用于诱导克罗恩病缓解或反应的氨基水杨酸盐。
Cochrane Database Syst Rev. 2016 Jul 3;7(7):CD008870. doi: 10.1002/14651858.CD008870.pub2.
5
Dextran Carrier Macromolecules for Colon-specific Delivery of 5-Aminosalicylic Acid.用于5-氨基水杨酸结肠特异性递送的葡聚糖载体大分子
Indian J Pharm Sci. 2013 May;75(3):277-83. doi: 10.4103/0250-474X.117420.
6
Synthesis and evaluation of mutual azo prodrug of 5-aminosalicylic acid linked to 2-phenylbenzoxazole-2-yl-5-acetic acid in ulcerative colitis.5-氨基水杨酸与2-苯基苯并恶唑-2-基-5-乙酸连接的相互偶氮前药在溃疡性结肠炎中的合成与评价
Drug Des Devel Ther. 2013 Jul 31;7:691-8. doi: 10.2147/DDDT.S48636. eCollection 2013.
7
Pharmacokinetic considerations in gastrointestinal motor disorders.胃肠运动障碍中的药代动力学考量
Clin Pharmacokinet. 1995 Jan;28(1):41-66. doi: 10.2165/00003088-199528010-00005.
8
Olsalazine and GI transit in UC.奥沙拉嗪与溃疡性结肠炎的胃肠道转运
Gut. 1988 May;29(5):695-6. doi: 10.1136/gut.29.5.695-a.
9
Newer 5-aminosalicylic acid based drugs in chronic inflammatory bowel disease.新型基于5-氨基水杨酸的药物在慢性炎症性肠病中的应用
Drugs. 1989 Jan;37(1):73-86. doi: 10.2165/00003495-198937010-00005.
10
Olsalazine or sulphasalazine in first attacks of ulcerative colitis? A double blind study.奥沙拉嗪或柳氮磺胺吡啶用于溃疡性结肠炎初发发作？一项双盲研究。
Gut. 1989 May;30(5):675-9. doi: 10.1136/gut.30.5.675.
本文引用的文献
1
Faecal stasis in proctocolitis.直肠结肠炎中的粪便淤滞。
Gut. 1962 Dec;3(4):301-5. doi: 10.1136/gut.3.4.301.
2
Observations on idiopathic proctitis.特发性直肠炎观察报告
Gut. 1962 Sep;3(3):201-6. doi: 10.1136/gut.3.3.201.
3
Transit of a meal through the stomach, small intestine, and colon in normal subjects and its role in the pathogenesis of diarrhea.正常受试者进餐通过胃、小肠和结肠的过程及其在腹泻发病机制中的作用。
Gastroenterology. 1980 Dec;79(6):1276-82.
4
Distribution and metabolism in healthy volunteers of disodium azodisalicylate, a potential therapeutic agent for ulcerative colitis.偶氮双水杨酸二钠在健康志愿者体内的分布与代谢，偶氮双水杨酸二钠是一种潜在的溃疡性结肠炎治疗药物。
Gut. 1982 Dec;23(12):1081-7. doi: 10.1136/gut.23.12.1081.
5
Irritable bowel syndrome: relationship of disorders in the transit of a single solid meal to symptom patterns.肠易激综合征：单次固体食物转运障碍与症状模式的关系。
Gut. 1983 May;24(5):405-11. doi: 10.1136/gut.24.5.405.
6
Sulfasalazine-induced colitis complicating idiopathic ulcerative colitis.柳氮磺胺吡啶诱发的结肠炎并发特发性溃疡性结肠炎。
Can Med Assoc J. 1984 Jul 1;131(1):43-5.
7
Sulfasalazine-induced exacerbation of ulcerative colitis.柳氮磺胺吡啶诱发的溃疡性结肠炎加重
N Engl J Med. 1982 Feb 18;306(7):409-12. doi: 10.1056/NEJM198202183060708.
8
9
Faecal stasis and diverticular disease in ulcerative colitis.溃疡性结肠炎中的粪便淤滞与憩室病
Gut. 1970 Aug;11(8):688-96. doi: 10.1136/gut.11.8.688.
10
Olsalazine in active ulcerative colitis.奥沙拉嗪治疗活动期溃疡性结肠炎。
Br Med J (Clin Res Ed). 1985 Nov 16;291(6506):1373-5. doi: 10.1136/bmj.291.6506.1373.
Zotero 插件