Khuffash F A, Barakat M H, Shaltout A A, Farwana S S, Adnani M S, Tungekar M F
Department of Paediatrics, Kuwait University, Safat.
Gut. 1987 Dec;28(12):1595-9. doi: 10.1136/gut.28.12.1595.
Twenty children with coeliac disease were diagnosed over a five year period in an area with 10,000-12,000 births per year. The average annual incidence was 1:3000 births. All children presented with severe symptoms and rickets was not uncommon (25%). Mean age at onset of symptoms was 38 months (range 6-120) and 72 months at the time of diagnosis (range 13-192), with a mean delay of 34 months. No cases were diagnosed during infancy. The difficulties in the differentiation of coeliac disease from the more common causes of chronic diarrhoea, and problems with diagnosis and management are discussed.
在一个每年有10000 - 12000例新生儿出生的地区,五年间诊断出20例乳糜泻患儿。年平均发病率为每3000例出生中有1例。所有患儿均表现出严重症状,佝偻病并不少见(25%)。症状出现的平均年龄为38个月(范围6 - 120个月),诊断时的平均年龄为72个月(范围13 - 192个月),平均延迟34个月。婴儿期无病例被诊断。文中讨论了乳糜泻与更常见的慢性腹泻病因鉴别诊断的困难以及诊断和管理方面的问题。