Costescu Strachinaru Diana Isabela, Wauters An, Van Esbroeck Marjan, Strachinaru Mihai, Vanbrabant Peter, Soentjens Patrick
Center for Infectious Diseases, Queen Astrid Military Hospital, 1120 Brussels, Belgium.
Department of Clinical Sciences, Institute of Tropical Medicine, 2000 Antwerp, Belgium.
Trop Med Infect Dis. 2021 Jul 8;6(3):125. doi: 10.3390/tropicalmed6030125.
malaria is often neglected due to its less severe course compared to . In 2011-2012, Belgian Armed Forces identified a cluster of cases among military personnel after deployment in the Democratic Republic of Congo (DRC). In this retrospective, monocentric, observational study, clinical and biological features of soldiers diagnosed with after deployment in DRC were reviewed. Species diagnosis was based on polymerase chain reaction (PCR) and/or thick blood smear. Medical records of 149 soldiers screened at the Queen Astrid Military Hospital after deployment were reviewed. Eight cases (seven infections and one coinfection) were identified. All had positive thick smears, and seven were confirmed by PCR. Chemoprophylaxis was mefloquine in all subjects. Median time of disease onset was 101 days after return from the endemic region. Median delay between return and diagnosis was 103 days. All bouts were uncomplicated. None had relapses after primaquine treatment. This military cohort highlights a hotspot of in Eastern DRC. Non-specific symptoms, the less severe presentation, the lack of sensitive parasitological tools in the field and long delays between infection and symptoms probably lead to underestimation of cases.
与……相比，疟疾因其病程不太严重而常常被忽视。2011 - 2012年，比利时武装部队在刚果民主共和国（DRC）部署后，在军事人员中发现了一批疟疾病例。在这项回顾性、单中心观察性研究中，对在刚果民主共和国部署后被诊断为疟疾的士兵的临床和生物学特征进行了回顾。物种诊断基于聚合酶链反应（PCR）和/或厚血涂片。对149名部署后在阿斯特丽德女王军事医院接受筛查的士兵的病历进行了回顾。确定了8例（7例单一感染和1例混合感染）。所有患者厚涂片均呈阳性，7例经PCR确诊。所有受试者的化学预防药物均为甲氟喹。疾病发作的中位时间为从流行地区返回后101天。返回与诊断之间的中位延迟为103天。所有疟疾发作均为非复杂性。在用伯氨喹治疗后均无复发。这个军事队列突出了刚果民主共和国东部的一个疟疾热点地区。非特异性症状、症状较轻、现场缺乏敏感的寄生虫学检测工具以及感染与症状之间的长时间延迟可能导致疟疾病例被低估。
