循环环状RNA（hsa_circ_0013587）水平升高可能作为胰腺癌的一种新型生物标志物。
Increased levels of circulating circular RNA (hsa_circ_0013587) may serve as a novel biomarker for pancreatic cancer.
作者信息
Xu Kaiwei, Qiu Zhoujian, Xu Liu, Qiu Xuedan, Hong Lu, Wang Jianhua
机构信息
Department of Radiology, The Affiliated Hospital of Medical School of Ningbo University, Ningbo University School of Medicine, Ningbo, Zhejiang Province, China.
Department of Radiology, Second Yinzhou District Hospital, Ningbo, Zhejiang Province, China.
出版信息
Biomark Med. 2021 Aug;15(12):977-985. doi: 10.2217/bmm-2020-0750. Epub 2021 Jul 22.
Circular RNA can serve as a biomarker for early diagnosis of pancreatic cancer. Analyzed the expression of various differentially expressed circular RNAs in the pancreatic cancer tissues by gene chip and identified the expression of hsa_circ_0013587 in pancreatic cancer cells, tissues and plasma by quantitative reverse transcription PCR (qRT-PCR). Hsa_circ_0013587 was highly expressed in the pancreatic cancer tissues, cell lines and plasma samples from patients with pancreatic cancer. Notably, hsa_circ_0013587 was upregulated in pancreatic cancer patients with later clinical stages III-IV as compared with those detected in early clinical stages I-II. A high expression of hsa_circ_0013587 may serve as a novel diagnostic and therapeutic biomarker for pancreatic cancer.
环状RNA可作为胰腺癌早期诊断的生物标志物。通过基因芯片分析胰腺癌组织中各种差异表达环状RNA的表达情况，并通过定量逆转录PCR（qRT-PCR）鉴定hsa_circ_0013587在胰腺癌细胞、组织和血浆中的表达。hsa_circ_0013587在胰腺癌组织、细胞系以及胰腺癌患者的血浆样本中高表达。值得注意的是，与临床早期I-II期患者相比，hsa_circ_0013587在临床晚期III-IV期的胰腺癌患者中表达上调。hsa_circ_0013587的高表达可能作为胰腺癌一种新的诊断和治疗生物标志物。
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