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环状RNA在胰腺癌发病机制及治疗中的作用

Roles of circular RNAs in the pathogenesis and treatment of pancreatic cancer.

作者信息

Seimiya Takahiro, Otsuka Motoyuki, Fujishiro Mitsuhiro

机构信息

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

出版信息

Front Cell Dev Biol. 2022 Nov 17;10:1023332. doi: 10.3389/fcell.2022.1023332. eCollection 2022.

DOI:10.3389/fcell.2022.1023332
PMID:36467402
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9712786/
Abstract

Circular RNAs are single-stranded RNAs with a covalently closed structure formed by the process of back-splicing. Aberrant expression of circular RNAs contributes to the pathogenesis of a wide range of cancers. Pancreatic cancer is one of the most lethal cancers due to diagnostic difficulties and limited therapeutic options. Circular RNAs are emerging as novel diagnostic biomarkers and therapeutic targets for pancreatic cancer. Moreover, recent advances in the therapeutic application of engineered circular RNAs have provided a promising approach to overcoming pancreatic cancer. This review discusses the roles of circular RNAs in the pathogenesis of pancreatic cancer and in potential treatment applications and their usefulness as diagnostic biomarkers.

摘要

环状RNA是通过反向剪接过程形成的具有共价闭合结构的单链RNA。环状RNA的异常表达与多种癌症的发病机制有关。胰腺癌是最致命的癌症之一，原因在于诊断困难且治疗选择有限。环状RNA正成为胰腺癌新的诊断生物标志物和治疗靶点。此外，工程化环状RNA治疗应用的最新进展为攻克胰腺癌提供了一种有前景的方法。本文综述讨论了环状RNA在胰腺癌发病机制及潜在治疗应用中的作用，以及它们作为诊断生物标志物的实用性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c1e/9712786/8fd501a2fa4b/fcell-10-1023332-g001.jpg

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