Assistance Publique-Hôpitaux de Paris, Centre de référence Maladies Rares (PRADORT, Syndrome de Prader-Willi et autres formes rares d'obésité avec troubles du comportement alimentaire), Service de Nutrition, Hôpital Pitié-Salpêtrière, ENDO-ERN (European Reference Network on Rare Endocrine Conditions), 47-83 boulevard de l'Hôpital, 75651, Paris Cedex 13, France.
Assistance Publique-Hôpitaux de Paris, Centre de référence Maladies Rares (PRADORT, Syndrome de Prader-Willi et autres formes rares d'obésité avec troubles du comportement alimentaire), Hôpital Marin d'Hendaye, ENDO-ERN (European Reference Network on Rare Endocrine Conditions), Hendaye, France.
Orphanet J Rare Dis. 2021 Jul 21;16(1):325. doi: 10.1186/s13023-021-01949-4.
Patients with Prader-Willi syndrome (PWS) often have comorbidities, especially obesity, that may constitute a risk factor for severe forms of COVID-19. We aimed to assess prevalence and medical course of SARS-CoV-2 infection in children and adults with PWS. From November 2020 to January 2021, we performed a detailed medical survey on 342 adults and 305 children with PWS followed in the French reference center.
We obtained responses from 288 adults (84%) and 239 children (78%). From March 2020 to January 2021, 38 adults (13.2%) and 13 children (5.4%) with PWS had SARS-CoV-2 infection. Mean age of adults was 34.1 ± 11.9 years and mean body mass index was 40.6 ± 12.7 kg/m; 82% had obesity and 37% had diabetes. Only 3 children (23%) had obesity and none had diabetes. Similar to the general population, the most frequent symptoms of COVID-19 were asthenia, fever, cough, headache and shortness of breath. All patients had a favorable outcome.
PWS itself is not a risk factor for severe COVID-19 in children and adults. On the contrary, evolution of SARS-CoV-2 infection in adults with PWS seems more favorable than expected, given their comorbidities.
普拉德-威利综合征（PWS）患者常合并多种疾病，尤其是肥胖症，这可能构成 COVID-19 重症的危险因素。我们旨在评估 PWS 儿童和成人中 SARS-CoV-2 感染的流行情况和病程。自 2020 年 11 月至 2021 年 1 月，我们对法国参考中心随访的 342 名成人和 305 名儿童进行了详细的医学调查。
我们获得了 288 名成人（84%）和 239 名儿童（78%）的回复。自 2020 年 3 月至 2021 年 1 月，38 名成人（13.2%）和 13 名儿童（5.4%）患有 SARS-CoV-2 感染。成人的平均年龄为 34.1±11.9 岁，平均体重指数为 40.6±12.7 kg/m；82%肥胖，37%患有糖尿病。仅有 3 名儿童（23%）肥胖，无一例患有糖尿病。与一般人群一样，COVID-19 的最常见症状为乏力、发热、咳嗽、头痛和呼吸急促。所有患者均预后良好。
PWS 本身不是儿童和成人 COVID-19 重症的危险因素。相反，考虑到 PWS 成人的合并症，SARS-CoV-2 感染在成人中的病程似乎比预期更为有利。
