Lapidus Nathanael, Paireau Juliette, Levy-Bruhl Daniel, de Lamballerie Xavier, Severi Gianluca, Touvier Mathilde, Zins Marie, Cauchemez Simon, Carrat Fabrice
Sorbonne Université, Inserm, Institut Pierre-Louis d'Epidémiologie et de Santé Publique, Département de Santé Publique, Hôpital Saint-Antoine, APHP, Paris, France.
Mathematical Modelling of Infectious Diseases Unit, Institut Pasteur, UMR2000, CNRS, Paris, France; Santé Publique France, French National Public Health Agency, Saint-Maurice, France.
Infect Dis Now. 2021 Jun;51(4):380-382. doi: 10.1016/j.idnow.2020.12.007. Epub 2021 Jan 18.
This study aimed at estimating the SARS-CoV-2 infection hospitalization (IHR) and infection fatality ratios (IFR) in France.
A serosurvey was conducted in 9782 subjects from the two French regions with the highest incidence of COVID-19 during the first wave of the pandemic and coupled with surveillance data.
IHR and IFR were 2.7% and 0.49% overall. Both were higher in men and increased exponentially with age. The relative risks of hospitalization and death were 2.1 (95% CI: 1.9-2.3) and 3.8 (2.4-4.2) per 10-year increase, meaning that IHR and IFR approximately doubled every 10 and 5 years, respectively. They were dramatically high in the very elderly (80-90 years: IHR: 26%, IFR: 9.2%), and also substantial in younger adults (40-50 years: IHR: 0.98%, IFR: 0.042%).
These findings support the need for comprehensive preventive measures to help reduce the spread of the virus, even in young or middle-aged adults.
本研究旨在估算法国的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染住院率（IHR）和感染死亡率（IFR）。
在疫情第一波期间，对法国两个新冠病毒病发病率最高的地区的9782名受试者进行了血清学调查，并结合监测数据。
总体IHR和IFR分别为2.7%和0.49%。两者在男性中均更高，且随年龄呈指数增长。每增加10岁，住院和死亡的相对风险分别为2.1（95%置信区间：1.9 - 2.3）和3.8（2.4 - 4.2），这意味着IHR和IFR分别约每10年和5年翻一番。在高龄老人（80 - 90岁：IHR：26%，IFR：9.2%）中极高，在年轻成年人（40 - 50岁：IHR：0.98%，IFR：0.042%）中也相当可观。
这些发现支持了采取全面预防措施以帮助减少病毒传播的必要性，即使在年轻人或中年成年人中也是如此。
