确定腹水型肝硬化患者中因质子泵抑制剂使用增加导致自发性细菌性腹膜炎的风险。

Determining the Risk of Spontaneous Bacterial Peritonitis due to increase use of Proton Pump Inhibitors among cirrhotic patients with ascites.

作者信息

Shaikh Bashir Ahmed, Shaikh Zahid Ali, Shah Aftab Hussain, Kumar Aneel

机构信息

Bashir Ahmed Shaikh, FCPS, FRCP. Chandka Medical College Hospital, Shaheed Mohtarma Benazir Bhutto Medical University (SMBBMU), Larkana, Sindh, Pakistan.

Zahid Ali Shaikh, FCPS. Chandka Medical College Hospital, Shaheed Mohtarma Benazir Bhutto Medical University (SMBBMU), Larkana, Sindh, Pakistan.

出版信息

Pak J Med Sci. 2021 Jul-Aug;37(4):1075-1079. doi: 10.12669/pjms.37.4.3476.

DOI:10.12669/pjms.37.4.3476

PMID:34290786

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8281193/

Abstract

OBJECTIVES

The current study aimed to determine the Spontaneous Bacterial Peritonitis (SBP) risk due to increased use of Proton Pump Inhibitors (PPIs) among cirrhotic patients with ascites.

METHODS

This retrospective case-control study was conducted at Chandka Medical College & Hospital, Larkana from March 2013 to February 2014, involving 215 cirrhotic patients with ascites. Paracentesis was performed to distinguish cirrhotic patients with SBP and Polymorphonuclear Neutrophil (PMN) count ≥ 250 neutrophils/mm (cases) and non-SBP with PMN count < 250 neutrophils/mm (controls). The demographic details, history of PPIs use before admission and duration of Chronic Liver Disease (CLD) were inquired and statistical analysis was carried through SPSS Version 23.0.

RESULTS

Increased pre-hospital PPI intake was observed among cirrhotic patients with SBP (69.8%) as compared to those without SBP (48.8%; p = 0.014). The mean duration of PPI use was 19.16 ± 4.772 days, and it was more significant among older cirrhotic patients (p < 0.05). Increased duration of CLD was observed among PPI users, i.e. 20.47 ± 6.305 months vs. 18.95 ± 5.527 months among non-PPI users (p < 0.05).

CONCLUSIONS

Our results show that cirrhotic patients with ascites consuming PPIs are more likely to develop SBP as compared to non-PPI users.

摘要

目的

本研究旨在确定腹水型肝硬化患者中因质子泵抑制剂（PPI）使用增加而导致自发性细菌性腹膜炎（SBP）的风险。

方法

本回顾性病例对照研究于2013年3月至2014年2月在拉尔卡纳的钱德卡医学院及医院进行，纳入215例腹水型肝硬化患者。通过腹腔穿刺术区分SBP且多形核中性粒细胞（PMN）计数≥250个中性粒细胞/mm的肝硬化患者（病例组）和PMN计数<250个中性粒细胞/mm的非SBP患者（对照组）。询问患者的人口统计学细节、入院前PPI使用史和慢性肝病（CLD）病程，并使用SPSS 23.0进行统计分析。

结果

与无SBP的肝硬化患者（48.8%）相比，SBP的肝硬化患者院前PPI摄入量增加（69.8%；p = 0.014）。PPI的平均使用时长为19.16±4.772天，在老年肝硬化患者中更显著（p<0.05）。PPI使用者的CLD病程更长，即PPI使用者为20.47±6.305个月，非PPI使用者为18.95±5.527个月（p<0.05）。