对单个细胞进行计数并计算其异质性：从表型频率到定量生物标志物的平均值。
Counting single cells and computing their heterogeneity: from phenotypic frequencies to mean value of a quantitative biomarker.
作者信息
Qian Hong, Cheng Yu-Chen
机构信息
Department of Applied Mathematics, University of Washington, Seattle, WA 98195-3925, USA.
出版信息
Quant Biol. 2020 Jul 13;8(2):172-176. doi: 10.1007/s40484-020-0196-3. Epub 2020 Apr 20.
Abstract
This tutorial presents a mathematical theory that relates the probability of sample frequencies, of phenotypes in an isogenic population of cells, to the probability distribution of the sample mean of a quantitative biomarker, when the is very large. An analogue to the statistical mechanics of canonical ensemble is discussed.
摘要
本教程提出了一种数学理论，当细胞的同基因群体非常大时，该理论将细胞同基因群体中表型的样本频率概率与定量生物标志物样本均值的概率分布联系起来。文中还讨论了与正则系综统计力学的类比。
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Counting single cells and computing their heterogeneity: from phenotypic frequencies to mean value of a quantitative biomarker.对单个细胞进行计数并计算其异质性：从表型频率到定量生物标志物的平均值。
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