Key Laboratory of Specialty Fiber Optics and Optical Access Networks, Joint International Research Laboratory of Specialty Fiber Optics and Advanced Communication, School of Communication and Information Engineering, Shanghai University, Shanghai, China.
Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China.
Hum Brain Mapp. 2021 Oct 15;42(15):5051-5062. doi: 10.1002/hbm.25599. Epub 2021 Jul 22.
The discovery of preclinical Alzheimer's disease (preAD) provides a wide time window for the early intervention of AD. The coupling relationships between glucose and oxygen metabolisms from hybrid PET/MRI can provide complementary information on the brain's physiological state for preAD. In this study, we purpose to explore the change of coupling relationship among 27 normal controls (NCs), 20 preADs, and 15 cognitive impairments (CIs). For each subject, we calculated the Spearman partial correlation between the fractional amplitude of low-frequency fluctuations (fALFF) and the regional homogeneity (ReHo) from functional image (fMRI), and the standard uptake value ratio (SUVR) from [18F] fluorodeoxyglucose positron emission tomography ( F-FDG PET), in the whole-brain and default mode network (DMN) as a novel potential biomarker. The diagnostic performance of this biomarker was evaluated by the receiver operating characteristic analysis. Significant Spearman correlations between the FDG SUVR and the fALFF/ReHo were found in 98% of subjects. For the DMN-based biomarker, there was a significant decreasing trend for the preAD and CI groups compared to the NC group, whereas no significant difference in preAD based on whole-brain. The correlation ρ value for the FDG SUVR/ReHo showed the highest area under curve of the preAD classification (0.787). The results imply the coupling relationship changed during the preAD stage in the DMN area.
临床前阿尔茨海默病（preAD）的发现为 AD 的早期干预提供了广泛的时间窗口。杂交 PET/MRI 的葡萄糖和氧代谢的耦合关系可为 preAD 大脑的生理状态提供补充信息。在这项研究中，我们旨在探索 27 名正常对照（NC）、20 名 preAD 和 15 名认知障碍（CI）患者之间耦合关系的变化。对于每个受试者，我们计算了功能图像（fMRI）中低频振幅（fALFF）和局部一致性（ReHo）与 [18F]氟脱氧葡萄糖正电子发射断层扫描（F-FDG PET）中标准摄取值比（SUVR）之间的 Spearman 偏相关，作为一种新的潜在生物标志物，在全脑和默认模式网络（DMN）中进行。通过接收者操作特征分析评估了该生物标志物的诊断性能。在 98%的受试者中，FDG SUVR 与 fALFF/ReHo 之间存在显著的 Spearman 相关性。对于基于 DMN 的生物标志物，与 NC 组相比，preAD 和 CI 组表现出明显的下降趋势，而在全脑水平上，preAD 之间没有显著差异。FDG SUVR/ReHo 的相关 ρ 值显示了 preAD 分类的最高曲线下面积（0.787）。结果表明，在 DMN 区域，preAD 阶段的耦合关系发生了变化。
