慢性应激负担、内脏脂肪组织与肥胖相关炎症：动脉粥样硬化的多民族研究。
Chronic Stress Burden, Visceral Adipose Tissue, and Adiposity-Related Inflammation: The Multi-Ethnic Study of Atherosclerosis.
机构信息
From the Joint Doctoral Program in Epidemiology, San Diego State University and University of California San Diego (Delker), San Diego; School of Medicine (AlYami), University of California San Diego; Department of Psychology (Gallo), San Diego State University, San Diego, California; Department of Psychology (Ruiz), University of Arizona, Tucson, Arizona; Department of Epidemiology (Szklo), Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; and Family Medicine and Public Health (Allison), University of California San Diego, San Diego, California.
出版信息
Psychosom Med. 2021 Oct 1;83(8):834-842. doi: 10.1097/PSY.0000000000000983.
OBJECTIVE
We investigated the role of chronic stress burden on adiposity and adiposity-related inflammation with two hypotheses: a) greater chronic stress is associated with higher central adiposity and selective accumulation of visceral adipose tissue (VAT) compared with subcutaneous adipose tissue (SAT), and b) associations between VAT and inflammatory biomarkers are exacerbated when chronic stress is high.
METHODS
Data come from 1809 participants included in a Multi-Ethnic Study of Atherosclerosis ancillary study of body composition and adiposity-related inflammation. Chronic psychosocial stress was measured with a five-item version of the Chronic Stress Burden Scale. First, we tested associations between chronic stress (three-level categorical variable) and VAT, SAT, and VAT/SAT ratio. Second, we tested whether associations between VAT and inflammatory biomarkers varied by level of chronic stress.
RESULTS
Participants were approximately 65 years, 50% female, and 40.5% White, 25.6% Hispanic, 21.2% African American, and 12.8% Chinese American. About half of the sample reported little to no stress, and a quarter and a fifth of the sample reported medium and high levels of stress. Higher levels of chronic stress were associated with greater VAT and SAT, but not VAT/SAT ratio. Greater levels of VAT were associated with increased levels of adiposity-related inflammation in a graded pattern. These associations did not vary by stress level.
CONCLUSIONS
Greater chronic stress burden is associated with both central and subcutaneous adiposity. We found no evidence that the associations between VAT and inflammatory biomarkers are exacerbated by chronic stress. Findings contribute to ongoing literature untangling pathways in which psychosocial stress contributes to adiposity-related inflammation.
目的
我们通过两个假设研究了慢性压力负担对肥胖和肥胖相关炎症的作用：a）与皮下脂肪组织（SAT）相比，更大的慢性压力与更高的中心性肥胖和内脏脂肪组织（VAT）的选择性积累有关；b）当慢性压力较高时，VAT 与炎症生物标志物之间的关联会加剧。
方法
数据来自一项多民族动脉粥样硬化研究的身体成分和肥胖相关炎症的辅助研究中的 1809 名参与者。慢性心理社会压力使用慢性压力负担量表的五分量表进行测量。首先，我们测试了慢性压力（三水平分类变量）与 VAT、SAT 和 VAT/SAT 比值之间的关联。其次，我们测试了 VAT 与炎症生物标志物之间的关联是否因慢性压力水平而异。
结果
参与者的年龄约为 65 岁，50%为女性，40.5%为白人，25.6%为西班牙裔，21.2%为非裔美国人，12.8%为华裔美国人。大约一半的样本报告压力较小或没有压力，四分之一和五分之一的样本报告压力中等和高。较高水平的慢性压力与更大的 VAT 和 SAT 相关，但与 VAT/SAT 比值无关。更高水平的 VAT 与肥胖相关炎症的水平呈梯度相关。这些关联不受压力水平的影响。
结论
更大的慢性压力负担与中心性肥胖和皮下肥胖都有关。我们没有发现证据表明 VAT 与炎症生物标志物之间的关联因慢性压力而加剧。这些发现有助于阐明心理社会压力导致肥胖相关炎症的途径的现有文献。
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