Grammatopoulou Eirini P, Skordilis Emmanouil K, Georgoudis Georgios, Haniotou Aikaterini, Evangelodimou Afroditi, Fildissis George, Katsoulas Theodoros, Kalagiakos Panagiotis
Department of Physical Therapy, Technological and Educational Institution - TEI of Athens , Athens , Greece .
J Asthma. 2014 Oct;51(8):839-46. doi: 10.3109/02770903.2014.922190. Epub 2014 May 29.
The Nijmegen questionnaire (NQ) has previously been used for screening the hyperventilation syndrome (HVS) in asthmatics. However, no validity study has been reported so far.
To examine the validity and reliability of the NQ in asthma patients and identify the prevalence of HVS.
The NQ (n = 162) was examined for translation, construct, cross-sectional and discriminant validity as well as for internal consistency and test-retest reliability.
Principal component analysis and exploratory factor analysis revealed a single factor solution with 11 items and 58.6% of explained variability. These 11 NQ items showed high internal consistency (Cronbach's alpha = 0.92) and test-retest reliability (IR = 0.98). Higher NQ scores were found in the following subgroups: women versus men (p < 0.01); participants with moderate versus mild asthma (p < 0.001) or uncontrolled versus controlled asthma (p < 0.001), and participants with breath-hold time (BHT) < 30 versus ≥ 30 s (p < 0.01) or end-tidal CO2 (ETCO2) ≤ 35 versus >35 mmHg (p < 0.001). A cut-off score of >17 discriminated the participants with regard to the presence of HVS. The NQ showed 92.73% sensitivity and 91.59% specificity. The total NQ score was found significantly correlated with ETCO2 (r = -0.68), RR (r = 0.66) and BHT (r = -0.65). The prevalence of HVS was found 34%.
The NQ is a valid and reliable questionnaire for screening HVS in patients with stable mild-to-moderate asthma.
奈梅亨问卷（NQ）此前已用于筛查哮喘患者的过度通气综合征（HVS）。然而，目前尚未有关于其效度的研究报告。
检验NQ在哮喘患者中的效度和信度，并确定HVS的患病率。
对NQ（n = 162）进行翻译效度、结构效度、横断面效度和判别效度检验，以及内部一致性和重测信度检验。
主成分分析和探索性因素分析显示，11个项目的单因素解决方案可解释58.6%的变异。这11个NQ项目显示出较高的内部一致性（Cronbach's α = 0.92）和重测信度（IR = 0.98）。在以下亚组中发现NQ得分较高：女性与男性（p < 0.01）；中度哮喘与轻度哮喘患者（p < 0.001）或未控制哮喘与控制良好哮喘患者（p < 0.001），以及屏气时间（BHT）< 30秒与≥ 30秒的参与者（p < 0.01）或呼气末二氧化碳（ETCO2）≤ 35 mmHg与> 35 mmHg的参与者（p < 0.001）。> 17的截断分数可区分有无HVS的参与者。NQ的敏感性为92.73%，特异性为91.59%。发现NQ总分与ETCO2（r = -0.68）、呼吸频率（RR）（r = 0.66）和BHT（r = -0.65）显著相关。HVS的患病率为34%。
NQ是一种有效且可靠的问卷，可用于筛查稳定的轻至中度哮喘患者的HVS。
