Zehravi Mehrukh, Maqbool Mudasir, Ara Irfat
Department of Clinical Pharmacy Girls Section, Prince Sattam Bin Abdul Aziz University Alkharj, Saudia Arabia.
Department of Pharmaceutical Sciences, University of Kashmir, Srinagar, Jammu and Kashmir, India.
Int J Adolesc Med Health. 2021 Jul 22;34(2):1-9. doi: 10.1515/ijamh-2021-0073.
Polycystic ovarian syndrome is the most well-known endocrine condition among women of this generation (PCOS). Symptoms of hyperandrogenism, irregular menstrual periods, and insulin resistance are all traits associated with PCOS. In women with PCOS, the chance of having problems including infertility, insulin resistance, and type 2 diabetes increases. The PCOS board hopes to reduce body weight and insulin levels, restore fertility, control excessive hair growth on the body or scalp, re-establish the regular feminine cycle, and avoid misunderstandings. Insulin sensitizers have been one of the most common metabolic modulators, but their effectiveness has been sporadic. Insulin resistance, followed by thiazolidinediones, is central to the pathophysiology of PCOS, with metformin having nearly similar efficacy. In the management of PCOS, statins and incretins are newer therapies with obvious metabolic targets. Vitamin D, acarbose, and myoinositol are just a few of the reciprocal and optional clinical treatments that have been proved to be useful in the treatment of PCOS. The number of viable methods for dealing with PCOS-related infertility has increased as well. Despite the fact that clomiphene citrate (CC) has long been the gold standard for ovulation induction in the event of ovulatory infertility, aromatase inhibitors can induce ovulation with results that are nearly identical to or better than those reported with CC, aromatase inhibitors can cause ovulation with results that are nearly identical to or better than those reported with CC. Ovarian incitement conventions that intelligently utilize gonadotropins, gonadotropin-delivering hormone rivals, the approach of ovarian boring, and assisted conceptive advancements with oocyte development indicate an expanding level of therapeutic progress.
多囊卵巢综合征(PCOS)是这一代女性中最广为人知的内分泌疾病。高雄激素血症、月经不规律和胰岛素抵抗等症状都是与PCOS相关的特征。患有PCOS的女性出现包括不孕、胰岛素抵抗和2型糖尿病等问题的几率会增加。PCOS研究小组希望减轻体重和降低胰岛素水平,恢复生育能力,控制身体或头皮上的过多毛发增长,重新建立规律的女性生理周期,并避免误解。胰岛素增敏剂一直是最常见的代谢调节剂之一,但其效果并不稳定。胰岛素抵抗是PCOS病理生理学的核心,其次是噻唑烷二酮类药物,二甲双胍的疗效与之相近。在PCOS的治疗中,他汀类药物和肠促胰岛素是具有明确代谢靶点的新型疗法。维生素D、阿卡波糖和肌醇只是已被证明对PCOS治疗有用的一些相互补充且可选择的临床治疗方法。处理与PCOS相关不孕的可行方法数量也有所增加。尽管枸橼酸氯米芬(CC)长期以来一直是排卵性不孕情况下诱导排卵的金标准,但芳香化酶抑制剂可以诱导排卵,其效果与CC相近或更好,芳香化酶抑制剂可以诱导排卵,其结果与CC相近或更好。智能利用促性腺激素、促性腺激素释放激素拮抗剂、卵巢打孔方法以及卵母细胞发育辅助生殖技术的卵巢刺激方案表明治疗进展水平不断提高。