Marceaux Claire, Weeden Clare E, Gordon Claire L, Asselin-Labat Marie-Liesse
Personalised Oncology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.
Department of Medical Biology, The University of Melbourne, Parkville, Australia.
Transl Lung Cancer Res. 2021 Jun;10(6):2819-2829. doi: 10.21037/tlcr-20-819.
T cell memory is critical in controlling infection and plays an important role in anti-tumor responses in solid cancers. While effector memory and central memory T cells circulate and patrol non-lymphoid and lymphoid organs respectively, tissue resident memory T cells (T) permanently reside in tissues and provide local protective immune responses. In a number of solid tumors, tumor-specific T cell memory responses likely play an important role in keeping tumors in check, limiting cancer cell dissemination and reducing risk of relapse. In non-small cell lung cancer (NSCLC), a subset of tumor infiltrating lymphocytes (TILs) display phenotypic and functional characteristics associated with lung T (T-like TILs), including the expression of tissue-specific homing molecules and immune exhaustion markers. High infiltration of T-like TILs correlates with better survival outcomes for lung cancer patients, indicating that T-like TILs may contribute to anti-tumor responses. However, a number of T-like TILs do not display tumor specificity and the exact role of T-like TILs in mediating anti-tumor response in lung cancer is unclear. Here we review the characteristics of T-like TILs in lung cancer, the role these cells play in mediating anti-tumor immunity and the therapeutic implications of T-like TILs in the use and development of immunotherapy for lung cancer.
T细胞记忆在控制感染方面至关重要，并且在实体癌的抗肿瘤反应中发挥重要作用。效应记忆T细胞和中枢记忆T细胞分别在非淋巴器官和淋巴器官中循环和巡逻，而组织驻留记忆T细胞（TRM）则永久驻留在组织中并提供局部保护性免疫反应。在许多实体瘤中，肿瘤特异性T细胞记忆反应可能在控制肿瘤、限制癌细胞扩散和降低复发风险方面发挥重要作用。在非小细胞肺癌（NSCLC）中，一部分肿瘤浸润淋巴细胞（TIL）表现出与肺TRM相关的表型和功能特征（TRM样TIL），包括组织特异性归巢分子和免疫耗竭标志物的表达。TRM样TIL的高浸润与肺癌患者更好的生存结果相关，表明TRM样TIL可能有助于抗肿瘤反应。然而，许多TRM样TIL并不表现出肿瘤特异性，并且TRM样TIL在介导肺癌抗肿瘤反应中的确切作用尚不清楚。在这里，我们综述了肺癌中TRM样TIL的特征、这些细胞在介导抗肿瘤免疫中的作用以及TRM样TIL在肺癌免疫治疗的应用和开发中的治疗意义。
