皮质快速放电小白蛋白阳性篮状细胞在癫痫中的作用。
Involvement of cortical fast-spiking parvalbumin-positive basket cells in epilepsy.
作者信息
Jiang X, Lachance M, Rossignol E
机构信息
Université de Montréal, Montréal, QC, Canada; CHU Ste-Justine Research Center, Montréal, QC, Canada.
CHU Ste-Justine Research Center, Montréal, QC, Canada.
出版信息
Prog Brain Res. 2016;226:81-126. doi: 10.1016/bs.pbr.2016.04.012. Epub 2016 Jun 7.
Abstract
GABAergic interneurons of the parvalbumin-positive fast-spiking basket cells subtype (PV INs) are important regulators of cortical network excitability and of gamma oscillations, involved in signal processing and cognition. Impaired development or function of PV INs has been associated with epilepsy in various animal models of epilepsy, as well as in some genetic forms of epilepsy in humans. In this review, we provide an overview of some of the experimental data linking PV INs dysfunction with epilepsy, focusing on disorders of the specification, migration, maturation, synaptic function, or connectivity of PV INs. Furthermore, we reflect on the potential therapeutic use of cell-type specific stimulation of PV INs within active networks and on the transplantation of PV INs precursors in the treatment of epilepsy and its comorbidities.
摘要
小白蛋白阳性快速放电篮状细胞亚型（PV中间神经元）的γ-氨基丁酸能中间神经元是皮层网络兴奋性和γ振荡的重要调节因子，参与信号处理和认知。在各种癫痫动物模型以及人类的某些遗传性癫痫中，PV中间神经元的发育或功能受损与癫痫有关。在这篇综述中，我们概述了一些将PV中间神经元功能障碍与癫痫联系起来的实验数据，重点关注PV中间神经元在规格、迁移、成熟、突触功能或连接性方面的紊乱。此外，我们思考了在活跃网络中对PV中间神经元进行细胞类型特异性刺激以及移植PV中间神经元前体在治疗癫痫及其合并症方面的潜在治疗用途。
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