State Key Laboratory of Electronic Thin Films and Integrated Devices, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan, P. R. China.
Analyst. 2021 Aug 21;146(16):5008-5032. doi: 10.1039/d1an00624j. Epub 2021 Jul 23.
Surface-enhanced Raman scattering (SERS) has become one of the most sensitive analytical techniques for identifying the chemical components, molecular structures, molecular conformations, and the interactions between molecules. However, great challenges still need to be addressed until it can be widely accepted by the absolute quantification of analytes. Recently, many efforts have been devoted to addressing these issues via various electromagnetic (EM), chemical (CM), and EM-CM hybrid coupling enhancement strategies. In comparison with uncoupled SERS devices, they offer key advantages in terms of sensitivity, reproducibility, uniformity, stability, controllability and reliability. This review provides an in-depth analysis of coupled SERS devices, including coupling enhancement mechanisms, materials and approaches. Finally, we also discuss the remaining bottlenecks and possible strategies for the development of coupling-enhanced SERS devices in the future.
表面增强拉曼散射（SERS）已成为识别化学组分、分子结构、分子构象以及分子间相互作用的最灵敏分析技术之一。然而，在实现分析物的绝对定量广泛接受之前，仍需要解决许多挑战。最近，人们通过各种电磁（EM）、化学（CM）和 EM-CM 混合耦合增强策略来致力于解决这些问题。与非耦合 SERS 器件相比，它们在灵敏度、重现性、均匀性、稳定性、可控性和可靠性方面具有关键优势。本综述深入分析了耦合 SERS 器件，包括耦合增强机制、材料和方法。最后，我们还讨论了未来发展耦合增强 SERS 器件的剩余瓶颈和可能策略。
