Norton Ryan D, Phan Hoa T, Gibbons Stephanie N, Haes Amanda J
Department of Chemistry, University of Iowa, Iowa City, Iowa, USA; email:
Annu Rev Phys Chem. 2022 Apr 20;73:141-162. doi: 10.1146/annurev-physchem-082720-033751. Epub 2021 Dec 22.
Surface-enhanced Raman scattering (SERS), a powerful technique for trace molecular detection, depends on chemical and electromagnetic enhancements. While recent advances in instrumentation and substrate design have expanded the utility, reproducibility, and quantitative capabilities of SERS, some challenges persist. In this review, advances in quantitative SERS detection are discussed as they relate to intermolecular interactions, surface selection rules, and target molecule solubility and accessibility. After a brief introduction to Raman scattering and SERS, impacts of surface selection rules and enhancement mechanisms are discussed as they relate to the observation of activation and deactivation of normal Raman modes in SERS. Next, experimental conditions that can be used to tune molecular affinity to and density near SERS substrates are summarized and considered while tuning these parameters is conveyed. Finally, successful examples of quantitative SERS detection are discussed, and future opportunities are outlined.
表面增强拉曼散射（SERS）是一种用于痕量分子检测的强大技术，它依赖于化学增强和电磁增强。尽管仪器仪表和基底设计方面的最新进展扩大了SERS的实用性、可重复性和定量能力，但仍存在一些挑战。在本综述中，将讨论定量SERS检测在分子间相互作用、表面选择规则以及目标分子溶解度和可及性方面的进展。在简要介绍拉曼散射和SERS之后，将讨论表面选择规则和增强机制对SERS中正常拉曼模式激活和失活观察的影响。接下来，总结并考虑可用于调节分子与SERS基底的亲和力和密度的实验条件，同时阐述调节这些参数的方法。最后，讨论定量SERS检测的成功实例，并概述未来的机遇。
