Center for Molecular Imaging and Nuclear Medicine, State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Suzhou, China.
Shanghai University of Medicine and Health Sciences (SUMHS), Shanghai, China.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2022 Jan;14(1):e1740. doi: 10.1002/wnan.1740. Epub 2021 Jul 23.
As a research hotspot, the development of magnetic resonance imaging (MRI) contrast agents has attracted great attention over the past decades for improving the accuracy of diagnosis. Ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles with core diameter smaller than 5.0 nm are expected to become a next generation of contrast agents owing to their excellent MRI performance, long blood circulation time upon proper surface modification, renal clearance capacity, and remarkable biosafety profile. On top of these merits, USPIO nanoparticles are used for developing not only T contrast agents, but also T /T switchable contrast agents via assembly/disassembly approaches. In recent years, as a new type of contrast agents, USPIO nanoparticles have shown considerable applications in the diagnosis of various diseases such as vascular pathological changes and inflammations apart from malignant tumors. In this review, we are focusing on the state-of-the-art developments and the latest applications of USPIO nanoparticles as MRI contrast agents to discuss their advantages and future prospects. This article is categorized under: Diagnostic Tools > In Vivo Nanodiagnostics and Imaging.
作为研究热点，磁共振成像（MRI）对比剂的发展在过去几十年中受到了极大关注，旨在提高诊断的准确性。超小超顺磁性氧化铁（USPIO）纳米颗粒的核心直径小于 5.0nm，有望成为下一代对比剂，因为其具有优异的 MRI 性能、适当表面修饰后的长血液循环时间、肾脏清除能力和显著的生物安全性。除了这些优点之外，USPIO 纳米颗粒还可通过组装/拆卸方法用于开发不仅是 T 对比剂，还有 T/T 开关对比剂。近年来，作为一种新型对比剂，USPIO 纳米颗粒在除恶性肿瘤以外的血管病变和炎症等各种疾病的诊断中显示出相当大的应用。在这篇综述中，我们重点介绍了 USPIO 纳米颗粒作为 MRI 对比剂的最新研究进展和应用，讨论了它们的优势和未来前景。本文属于以下分类：诊断工具 > 体内纳米诊断和成像。
