Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Institute of Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Korea.
Yonsei Med J. 2021 Aug;62(8):702-707. doi: 10.3349/ymj.2021.62.8.702.
We aimed to determine the relationship between environmental exposure and nontuberculous mycobacterial pulmonary disease (NTM-PD) in Korea.
A group of 150 patients with NTM-PD and a control group of 217 patients with other respiratory diseases were prospectively enrolled between June 2018 and December 2020 in Seoul, Korea. They were surveyed with a standardized questionnaire, and their medical records were reviewed. Odds ratio (OR) and 95% confidence intervals (CI) were calculated with multivariate logistic regression analysis.
The mean ages of the NTM-PD and control groups were similar (63.8±9.2 years vs. 63.5±10.0 years; =0.737), and most patients were female (76.0% vs. 68.7%; =0.157) and nonsmokers (82.0% vs. 72.8%; =0.021). (49.3%) was the most commonly identified strain among NTM-PD patients, followed by (32.0%) and subspecies (12.7%). There were no differences in housing type or frequency of soil- or pet-related exposure between the case and the control groups. However, in subgroup analysis excluding patients with infection, more case patients frequently visited public baths ≥1 time/week (35.3% vs. 19.4%, =0.003); this remained significant after multivariate analysis (OR, 2.84; 95% CI, 1.58-5.17).
Frequent exposure to water at public baths might affect the odds of contracting NTM-PD, excluding individuals infected with strains.
我们旨在确定韩国环境暴露与非结核分枝杆菌肺病（NTM-PD）之间的关系。
2018 年 6 月至 2020 年 12 月，在韩国首尔前瞻性纳入了一组 150 例 NTM-PD 患者和一组 217 例其他呼吸系统疾病患者作为对照组。他们接受了标准化问卷调查，并对其病历进行了回顾。采用多变量逻辑回归分析计算比值比（OR）和 95%置信区间（CI）。
NTM-PD 组和对照组的平均年龄相似（63.8±9.2 岁 vs. 63.5±10.0 岁；=0.737），大多数患者为女性（76.0% vs. 68.7%；=0.157）和不吸烟者（82.0% vs. 72.8%；=0.021）。NTM-PD 患者中最常见的菌株是 （49.3%），其次是 （32.0%）和 亚种 （12.7%）。病例组和对照组在住房类型或土壤或宠物相关暴露频率方面无差异。然而，在排除 感染患者的亚组分析中，更多的病例患者经常每周至少 1 次去公共浴室（35.3% vs. 19.4%，=0.003）；这在多变量分析后仍然显著（OR，2.84；95%CI，1.58-5.17）。
经常暴露于公共浴室的水中可能会影响感染 以外的 NTM-PD 菌株的几率。
