Wang Xuecong, Thiery Jean Paul
Bioland Laboratory, Guangzhou Regenerative Medicine and Health, Huangpu District, Guangzhou 510700, China.
Cancers (Basel). 2021 Jul 7;13(14):3397. doi: 10.3390/cancers13143397.
Epithelial cell plasticity, a hallmark of carcinoma progression, results in local and distant cancer dissemination. Carcinoma cell plasticity can be achieved through epithelial-mesenchymal transition (EMT), with cells positioned seemingly indiscriminately across the spectrum of EMT phenotypes. Different degrees of plasticity are achieved by transcriptional regulation and feedback-loops, which confer carcinoma cells with unique properties of tumor propagation and therapy resistance. Decoding the molecular and cellular basis of EMT in carcinoma should enable the discovery of new therapeutic strategies against cancer. In this review, we discuss the different attributes of plasticity in carcinoma and highlight the role of the canonical TGFβ receptor signaling pathway in the acquisition of plasticity. We emphasize the potential stochasticity of stemness in carcinoma in relation to plasticity and provide data from recent clinical trials that seek to target plasticity.
上皮细胞可塑性是癌症进展的一个标志，会导致局部和远处的癌症扩散。癌细胞可塑性可通过上皮-间质转化（EMT）实现，细胞似乎无差别地处于EMT表型谱中。不同程度的可塑性是通过转录调控和反馈回路实现的，这赋予癌细胞肿瘤增殖和治疗抗性的独特特性。解码癌症中EMT的分子和细胞基础应能发现对抗癌症的新治疗策略。在本综述中，我们讨论了癌症中可塑性的不同属性，并强调了经典TGFβ受体信号通路在获得可塑性中的作用。我们强调癌症中干性与可塑性相关的潜在随机性，并提供来自近期旨在靶向可塑性的临床试验的数据。
