Silva-Santana Giorgio, Silva Cecília Maria Ferreira, Olivella Julianna Giordano Botelho, Silva Igor Ferreira, Fernandes Laís Menegoi Oliveira, Sued-Karam Bruna Ribeiro, Santos Cíntia Silva, Souza Cassius, Mattos-Guaraldi Ana Luíza
Laboratory of Diphtheria and Corynebacteria of Clinical Relevance, Faculty of Medical Sciences, University of the State of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
The Collaborating Centre for Reference and Research on Diphtheria/National Health Foundation/Ministry of Health, Rio de Janeiro, Brazil.
Arch Microbiol. 2021 Jul;203(5):1863-1880. doi: 10.1007/s00203-021-02246-1. Epub 2021 Feb 24.
Corynebacterium striatum is part of microbiota of skin and nasal mucosa of humans and has been increasingly reported as the etiologic agent of community-acquired and nosocomial diseases. Antimicrobial multidrug-resistant (MDR) C. striatum strains have been increasingly related to various nosocomial diseases and/or outbreaks worldwide, including fatal invasive infections in immunosuppressed and immunocompetent patients. Although cases of infections by C. striatum still neglected in some countries, the improvement of microbiological techniques and studies led to the increase of survival of patients with C. striatum nosocomial infections at different levels of magnitude. Biofilm formation on abiotic surfaces contributes for the persistence of virulent C. striatum and dissemination of antimicrobial resistance in hospital environment. Besides that, empirical antibiotic therapy can select multi-resistant strains and transfer intra and interspecies genes horizontally. In this study, a worldwide survey of C. striatum human infections and nosocomial outbreaks was accomplished by the analysis of clinical-epidemiological and microbiological features of reported cases from varied countries, during a 44-year period (1976-2020).
纹带棒状杆菌是人类皮肤和鼻粘膜微生物群的一部分，越来越多地被报道为社区获得性和医院感染性疾病的病原体。抗菌多药耐药（MDR）纹带棒状杆菌菌株与全球范围内的各种医院感染性疾病和/或暴发越来越相关，包括免疫抑制和免疫功能正常患者的致命侵袭性感染。尽管在一些国家，纹带棒状杆菌感染病例仍被忽视，但微生物技术和研究的改进使得不同程度的纹带棒状杆菌医院感染患者的生存率有所提高。在非生物表面形成生物膜有助于毒性纹带棒状杆菌的持续存在以及医院环境中抗菌药物耐药性的传播。除此之外，经验性抗生素治疗可选择多重耐药菌株并水平转移种内和种间基因。在本研究中，通过分析44年期间（1976 - 2020年）不同国家报告病例的临床流行病学和微生物学特征，完成了一项关于纹带棒状杆菌人类感染和医院感染暴发的全球调查。
