School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea.
Molecules. 2021 Feb 1;26(3):756. doi: 10.3390/molecules26030756.
(Franch.) Skeels is a multi-purpose traditional medicine that has long been used for the treatment of various diseases. To discover the potential bioactive composition of , a chemical investigation was thus performed. In this research, two new stilbene oligomers, Davidiol E-F (-), one new 4-aryl-substituted isoflavan Davidinin A (), and one new 2-arylbenzofuran dimer, Shandougenine C (), as well as six known compounds (-) were obtained from the ethyl acetate fraction of (Franch.) Skeels. The structures of new compounds were established by extensive 1D and 2D nuclear magnetic resonance (NMR) spectra with mass spectroscopy data. The absolute configuration of - was assigned by comparing its experimental and calculated electronic circular dichroism (ECD) spectra. Compounds - promoted glucose transporter 4 (GLUT-4) translocations by the range of 1.28-2.60 folds, respectively. Compound showed the most potent glucose transporter 4 translocations with 1.60 fold enhancement. The result attained in this study indicated that the separation and characterization of these compounds plays an important role in the research and development of new anti-diabetic drugs and pharmaceutical industry.
（法属）Skeels 是一种多用途的传统药物，长期以来一直用于治疗各种疾病。为了发现其潜在的生物活性成分，我们对其进行了化学研究。在这项研究中，从（法属）Skeels 的乙酸乙酯部分中分离得到了两个新的二苯乙烯寡聚物（Davidiol E-F（-））、一个新的 4-芳基取代异黄酮 Davidinin A（）和一个新的 2-芳基苯并呋喃二聚体 Shandougenine C（），以及六个已知化合物（-）。通过与质谱数据相结合的 1D 和 2D 核磁共振（NMR）光谱确定了新化合物的结构。通过比较其实验和计算的电子圆二色性（ECD）光谱，确定了 - 的绝对构型。化合物 - 分别促进葡萄糖转运蛋白 4（GLUT-4）的易位 1.28-2.60 倍。化合物 显示出最强的葡萄糖转运蛋白 4 易位作用，增强了 1.60 倍。本研究结果表明，这些化合物的分离和鉴定在新型抗糖尿病药物的研究和开发以及制药工业中具有重要作用。
